Prostacyclin synthesis induced in vascular cells by interleukin-1

V. Rossi, F. Breviario, P. Ghezzi, E. Dejana, A. Mantovani

Research output: Contribution to journalArticle

231 Citations (Scopus)

Abstract

Supernatants from cultures of human monocytes that had been stimulated with endotoxin or silica induced the synthesis of prostacyclin in endothelial and smooth muscle cells. The lymphokine mediating these effects on the cells of the blood vessel wall was identified as interleukin-1; interferons and interleukin-2 were inactive. Interleukin-1-induced prostacyclin synthesis represents a new aspect of the interaction between the immune system (as well as other tissues) and the vessel wall and may serve as a basis for the development of new strategies in antithrombotic therapy.

Original languageEnglish
Pages (from-to)174-176
Number of pages3
JournalScience
Volume229
Issue number4709
DOIs
Publication statusPublished - 1985

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Epoprostenol
Interleukin-1
Blood Vessels
Lymphokines
Endotoxins
Silicon Dioxide
Interferons
Smooth Muscle Myocytes
Interleukin-2
Monocytes
Immune System
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Prostacyclin synthesis induced in vascular cells by interleukin-1. / Rossi, V.; Breviario, F.; Ghezzi, P.; Dejana, E.; Mantovani, A.

In: Science, Vol. 229, No. 4709, 1985, p. 174-176.

Research output: Contribution to journalArticle

Rossi, V. ; Breviario, F. ; Ghezzi, P. ; Dejana, E. ; Mantovani, A. / Prostacyclin synthesis induced in vascular cells by interleukin-1. In: Science. 1985 ; Vol. 229, No. 4709. pp. 174-176.
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