Prostaglandin and thromboxane synthesis by human intracranial tumors

M. G. Castelli, C. Chiabrando, R. Fanelli, L. Martelli, G. Butti, P. Gaetani, P. Paoletti

Research output: Contribution to journalArticle

Abstract

Prostaglandin (PG) and thromboxane (TX) production by homogenates of human intracranial tumors (33 gliomas, 32 meningiomas, six brain metastases) and 'normal' brain (n = 26) from tumor-bearing patients was studied. PGF(2α), PGE2, PGD2, 6-keto-PGF(1α) (the hydrolysis product of PGI2) and TXB2 (the hydrolysis product of TXA2) were determined by high-resolution gas chromatography-mass spectrometry after ex vivo metabolism of endogenous arachidonic acid. Prostanoid profiles (relative abundance of each metabolite) were different for gliomas and meningiomas, but similar for gliomas and their nontumoral counterpart, i.e., 'normal' brain. Mean overall prostanoid production was significantly higher in gliomas (539 ± 95) and meningiomas (523 ± 69) than in 'normal' brain (198 ± 23). Prostanoid synthesis significantly increased with anaplastic grade (glioblastomas > anaplastic astrocytomas > slow-growing astrocytomas > 'normal' brain), while profiles did not substantially change (TXB2 was the most and 6-keto-PGF(1α) the least abundant product). Meningioma profiles showed no marked prevalence of any particular metabolite and no major differences between histological subgroups. All brain metastases from different carcinomas (n = 5) showed a prevalence of TXB2 and PGE2 and very low PGD2 synthesis.

Original languageEnglish
Pages (from-to)1505-1508
Number of pages4
JournalCancer Research
Volume49
Issue number6
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Castelli, M. G., Chiabrando, C., Fanelli, R., Martelli, L., Butti, G., Gaetani, P., & Paoletti, P. (1989). Prostaglandin and thromboxane synthesis by human intracranial tumors. Cancer Research, 49(6), 1505-1508.