Prostaglandin endoperoxide synthetase and the activation of benzo(a)pyrene to reactive metabolites in vivo in guinea pigs

E. Garattini, P. Coccia, M. Romano, L. Jiritano, A. Noseda, M. Salmona

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The role of prostaglandin endoperoxide synthetase in the in vivo activation of benzo(a)pyrene to reactive metabolites capable of interacting irreversibly with cellular macromolecules was studied in guinea pig liver, lung, kidney, spleen, small intestine, colon, and brain. DNA and protein covalent binding experiments were made after systemic administration of acetylsalicylic acid (200 mg/kg) followed by radiolabeled benzo(a)pyrene (4 μg/kg). Results are compared with a control situation in which the prostaglandin endoperoxide synthetase inhibitor (acetylsalicylic acid) was not administered. No decrease in the level of DNA or protein benzo(a)pyrene-derived covalent binding was observed in any of the tissues studied.

Original languageEnglish
Pages (from-to)5150-5155
Number of pages6
JournalCancer Research
Volume44
Issue number11
Publication statusPublished - 1984

Fingerprint

Benzo(a)pyrene
Prostaglandin-Endoperoxide Synthases
Guinea Pigs
Aspirin
DNA-Binding Proteins
Small Intestine
Colon
Spleen
Kidney
Lung
Liver
DNA
Brain
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Prostaglandin endoperoxide synthetase and the activation of benzo(a)pyrene to reactive metabolites in vivo in guinea pigs. / Garattini, E.; Coccia, P.; Romano, M.; Jiritano, L.; Noseda, A.; Salmona, M.

In: Cancer Research, Vol. 44, No. 11, 1984, p. 5150-5155.

Research output: Contribution to journalArticle

@article{041f86f385ca433f877fbbb9164a803a,
title = "Prostaglandin endoperoxide synthetase and the activation of benzo(a)pyrene to reactive metabolites in vivo in guinea pigs",
abstract = "The role of prostaglandin endoperoxide synthetase in the in vivo activation of benzo(a)pyrene to reactive metabolites capable of interacting irreversibly with cellular macromolecules was studied in guinea pig liver, lung, kidney, spleen, small intestine, colon, and brain. DNA and protein covalent binding experiments were made after systemic administration of acetylsalicylic acid (200 mg/kg) followed by radiolabeled benzo(a)pyrene (4 μg/kg). Results are compared with a control situation in which the prostaglandin endoperoxide synthetase inhibitor (acetylsalicylic acid) was not administered. No decrease in the level of DNA or protein benzo(a)pyrene-derived covalent binding was observed in any of the tissues studied.",
author = "E. Garattini and P. Coccia and M. Romano and L. Jiritano and A. Noseda and M. Salmona",
year = "1984",
language = "English",
volume = "44",
pages = "5150--5155",
journal = "Journal of Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "11",

}

TY - JOUR

T1 - Prostaglandin endoperoxide synthetase and the activation of benzo(a)pyrene to reactive metabolites in vivo in guinea pigs

AU - Garattini, E.

AU - Coccia, P.

AU - Romano, M.

AU - Jiritano, L.

AU - Noseda, A.

AU - Salmona, M.

PY - 1984

Y1 - 1984

N2 - The role of prostaglandin endoperoxide synthetase in the in vivo activation of benzo(a)pyrene to reactive metabolites capable of interacting irreversibly with cellular macromolecules was studied in guinea pig liver, lung, kidney, spleen, small intestine, colon, and brain. DNA and protein covalent binding experiments were made after systemic administration of acetylsalicylic acid (200 mg/kg) followed by radiolabeled benzo(a)pyrene (4 μg/kg). Results are compared with a control situation in which the prostaglandin endoperoxide synthetase inhibitor (acetylsalicylic acid) was not administered. No decrease in the level of DNA or protein benzo(a)pyrene-derived covalent binding was observed in any of the tissues studied.

AB - The role of prostaglandin endoperoxide synthetase in the in vivo activation of benzo(a)pyrene to reactive metabolites capable of interacting irreversibly with cellular macromolecules was studied in guinea pig liver, lung, kidney, spleen, small intestine, colon, and brain. DNA and protein covalent binding experiments were made after systemic administration of acetylsalicylic acid (200 mg/kg) followed by radiolabeled benzo(a)pyrene (4 μg/kg). Results are compared with a control situation in which the prostaglandin endoperoxide synthetase inhibitor (acetylsalicylic acid) was not administered. No decrease in the level of DNA or protein benzo(a)pyrene-derived covalent binding was observed in any of the tissues studied.

UR - http://www.scopus.com/inward/record.url?scp=0021686549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021686549&partnerID=8YFLogxK

M3 - Article

VL - 44

SP - 5150

EP - 5155

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0008-5472

IS - 11

ER -