Prostanoids in jejunal biopsy specimens of celiac children with active disease and on challenge diet: Radioimmunologic evaluation

R. Pietroletti, M. Castro, P. Mariani, V. Lucidi, M. D. D'alessandro, F. Carlei, D. Lomanto, E. Lezoche, V. Speranza

Research output: Contribution to journalArticlepeer-review

Abstract

Prostanoid generation (prostaglandin E, and thromboxane B2) in jejunal biopsy specimens from celiac patients was evaluated, comparing celiac patients with celiac patients on challenge diet and controls. Generation of prostaglandin E, in jejunal specimens from 14 children with active celiac disease was significantly higher (341.8 ± 82.3 ng/g; mean ± SEM) than that from 7 celiac patients on gluten challenge diet (69.4 ± 13.2 ng/g) or 8 normal children (92 ± 23 ng/g) (p <0.05). In contrast, thromboxane B, generation in jejunal specimens from all three groups did not show any statistically significant variation. Our results indicate that prostaglandin E2 generation is not merely related to the activity of clinical symptoms, since patients receiving gluten challenge had prostaglandin E2 levels that did not differ from those of controls.

Original languageEnglish
Pages (from-to)1181-1184
Number of pages4
JournalScandinavian Journal of Gastroenterology
Volume22
Issue number10
DOIs
Publication statusPublished - 1987

Keywords

  • Celiac disease
  • Intestinal
  • Intestine
  • Mucosa
  • Prostaglandins
  • Radioimmunoassay
  • Small

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Prostanoids in jejunal biopsy specimens of celiac children with active disease and on challenge diet: Radioimmunologic evaluation'. Together they form a unique fingerprint.

Cite this