Prostate cancer detection rates in different biopsy schemes. Which cores for which patients?

Luigi Cormio, Vincenzo Scattoni, Fabrizio Lorusso, Antonia Perrone, Giuseppe Di Fino, Oscar Selvaggio, Francesca Sanguedolce, Pantaleo Bufo, Francesco Montorsi, Giuseppe Carrieri

Research output: Contribution to journalArticlepeer-review


Purpose: To determine whether the addition of four paramedian peripheral and four lateral peripheral cores improves the cancer detection rate (CDR) of the extended 10-core biopsy scheme and which patients benefit most from such additional samples. Methods: One thousand and ninety-one consecutive patients scheduled for first ultrasound-guided transrectal prostate biopsy prospectively underwent a 18-core biopsy scheme, including the traditional sextant (6-core), 4 lateral peripheral (10-core), 4 paramedian peripheral (14-core) and additional 4 lateral peripheral cores (18-core). Results: The CDR of the 6-, 10-, 14- and 18-core schemes was 33.1, 39.2, 41.6 and 41.8 %, respectively; the difference between the 10- and 6-core scheme reached significance (p <0.005), whereas that between the 18- or 14- and the 10-core scheme did not. The percentage of tumors diagnosed on the sole basis of the 14-core scheme was significantly greater in patients with low PSA (≤7.2 vs. >7.2 ng/ml: 12.1 vs. 1.8 %; p <0.0001), large prostate volume (≥50 vs.

Original languageEnglish
Pages (from-to)341-346
Number of pages6
JournalWorld Journal of Urology
Issue number2
Publication statusPublished - 2014


  • Diagnosis
  • Prostate biopsy
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Urology


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