Prostate cancer: From Gleason scoring to prognostic grade grouping

Rodolfo Montironi, Matteo Santoni, Roberta Mazzucchelli, Luciano Burattini, Rossana Berardi, Andrea B. Galosi, Liang Cheng, Antonio Lopez-Beltran, Alberto Briganti, Francesco Montorsi, Marina Scarpelli

Research output: Contribution to journalArticlepeer-review


The Gleason grading system was developed in the late 1960s by Dr. Donald F. Gleason. Due to changes in prostatic adenocarcinoma (PAC) detection and treatment, newer technologies to better characterize prostatic pathology, subsequently described variants of PAC and further data relating various morphologic patterns to prognosis, the application of the Gleason grading system changed substantially in surgical pathology. First in 2005 and more recently in 2014, consensus conferences were held to update PAC grading. Here, we review of the successive changes in the grading of PAC from the original system, with emphasis on the newest prognostic grade grouping.

Original languageEnglish
Pages (from-to)433-440
Number of pages8
JournalExpert Review of Anticancer Therapy
Issue number4
Publication statusPublished - Apr 2 2016


  • 2005 ISUP Gleason modified system
  • 2014 ISUP Gleason modified system
  • Gleason grading
  • International society of urological pathology
  • prognostic grade grouping
  • Prostate cancer

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology


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