Prostate health index (phi) and prostate cancer antigen 3 (PCA3) significantly improve diagnostic accuracy in patients undergoing prostate biopsy

Sisto Perdonà, Dario Bruzzese, Matteo Ferro, Riccardo Autorino, Ada Marino, Claudia Mazzarella, Giuseppe Perruolo, Michele Longo, Rosa Spinelli, Giuseppe Di Lorenzo, Andrea Oliva, Marco De Sio, Rocco Damiano, Vincenzo Altieri, Daniela Terracciano

Research output: Contribution to journalArticlepeer-review

Abstract

Background Prostate health index (phi) and prostate cancer antigen 3 (PCA3) have been recently proposed as novel biomarkers for prostate cancer (PCa). We assessed the diagnostic performance of these biomarkers, alone or in combination, in men undergoing first prostate biopsy for suspicion of PCa. Methods One hundred sixty male subjects were enrolled in this prospective observational study. PSA molecular forms, phi index (Beckman coulter immunoassay), PCA3 score (Progensa PCA3 assay), and other established biomarkers (tPSA, fPSA, and %fPSA) were assessed before patients underwent a 18-core first prostate biopsy. The discriminating ability between PCa-negative and PCa-positive biopsies of Beckman coulter phi and PCA3 score and other used biomarkers were determined. Results One hundred sixty patients met inclusion criteria. %p2PSA (p2PSA/fPSA × 100), phi and PCA3 were significantly higher in patients with PCa compared to PCa-negative group (median values: 1.92 vs. 1.55, 49.97 vs. 36.84, and 50 vs. 32, respectively, P ≤ 0.001). ROC curve analysis showed that %p2PSA, phi, and PCA3 are good indicator of malignancy (AUCs = 0.68, 0.71, and 0.66, respectively). A multivariable logistic regression model consisting of both the phi index and PCA3 score allowed to reach an overall diagnostic accuracy of 0.77. Decision curve analysis revealed that this "combined" marker achieved the highest net benefit over the examined range of the threshold probability. Conclusions phi and PCA3 showed no significant difference in the ability to predict PCa diagnosis in men undergoing first prostate biopsy. However, diagnostic performance is significantly improved by combining phi and PCA3. Prostate 73: 227-235, 2013. © 2012 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)227-235
Number of pages9
JournalProstate
Volume73
Issue number3
DOIs
Publication statusPublished - Feb 15 2013

Keywords

  • p2PSA
  • PCA3
  • phi
  • prostate biopsy
  • prostate cancer

ASJC Scopus subject areas

  • Urology
  • Oncology

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