Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue

He Yu, Eleftherios P. Diamandis, Michael Levesque, Maurizia Giai, Riccardo Roagna, Riccardo Ponzone, Piero Sismondi, Maria Monne, Carlo M. Croce

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Prostate specific antigen (PSA) is a tumor marker used widely for the diagnosis and monitoring of prostatic adenocarcinoma. Recently, we provided evidence that PSA may also be produced by breast tumors. In this report we examined quantitatively the PSA levels in 199 breast tumors, 48 tissues with benign breast disease (BBD, 34 fibroadenomas), and 36 normal breast tissues. Significant amounts of PSA (≤ 0.030 ng of PSA per mg of total protein) were found in 28% of breast tumors, 65% of BBD tissues, and 33% of normal breast tissues. PSA positivity in breast tumors was highest in stage I disease (34%) and decreased with disease stage (24% in stage II and 18% in stage III-IV). Using polymerase chain reaction amplification we have shown PSA mRNA presence in patients with PSA protein-positive tissues (benign and malignant) but not in patients with PSA protein-negative tissues. Our data suggest that PSA is expressed frequently by normal breast tissue, by tissue of benign breast diseases, and by breast cancer tissue. Highest expression is seen in benign breast disease and lowest expression in advanced stage cancerous tissue. As PSA production is mediated by steroid hormones and their receptors, we propose that PSA may be a new marker of steroid hormone action in the normal or diseased female breast. The role of this enzyme in the development of breast diseases including breast cancer is currently unknown.

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalBreast Cancer Research and Treatment
Volume40
Issue number2
Publication statusPublished - 1996

Fingerprint

Breast Diseases
Prostate-Specific Antigen
Breast
Breast Neoplasms
Steroids
Hormones
Fibroadenoma
Proteins
Tumor Biomarkers
Adenocarcinoma

Keywords

  • Benign breast disease
  • Breast cancer
  • Fibroadenomas
  • Prostate specific antigen
  • Steroid hormone receptors
  • Steroid hormones

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Yu, H., Diamandis, E. P., Levesque, M., Giai, M., Roagna, R., Ponzone, R., ... Croce, C. M. (1996). Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue. Breast Cancer Research and Treatment, 40(2), 171-178.

Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue. / Yu, He; Diamandis, Eleftherios P.; Levesque, Michael; Giai, Maurizia; Roagna, Riccardo; Ponzone, Riccardo; Sismondi, Piero; Monne, Maria; Croce, Carlo M.

In: Breast Cancer Research and Treatment, Vol. 40, No. 2, 1996, p. 171-178.

Research output: Contribution to journalArticle

Yu, H, Diamandis, EP, Levesque, M, Giai, M, Roagna, R, Ponzone, R, Sismondi, P, Monne, M & Croce, CM 1996, 'Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue', Breast Cancer Research and Treatment, vol. 40, no. 2, pp. 171-178.
Yu, He ; Diamandis, Eleftherios P. ; Levesque, Michael ; Giai, Maurizia ; Roagna, Riccardo ; Ponzone, Riccardo ; Sismondi, Piero ; Monne, Maria ; Croce, Carlo M. / Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue. In: Breast Cancer Research and Treatment. 1996 ; Vol. 40, No. 2. pp. 171-178.
@article{df7580a4e8cf42f59b32f8ec1de2d2e4,
title = "Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue",
abstract = "Prostate specific antigen (PSA) is a tumor marker used widely for the diagnosis and monitoring of prostatic adenocarcinoma. Recently, we provided evidence that PSA may also be produced by breast tumors. In this report we examined quantitatively the PSA levels in 199 breast tumors, 48 tissues with benign breast disease (BBD, 34 fibroadenomas), and 36 normal breast tissues. Significant amounts of PSA (≤ 0.030 ng of PSA per mg of total protein) were found in 28{\%} of breast tumors, 65{\%} of BBD tissues, and 33{\%} of normal breast tissues. PSA positivity in breast tumors was highest in stage I disease (34{\%}) and decreased with disease stage (24{\%} in stage II and 18{\%} in stage III-IV). Using polymerase chain reaction amplification we have shown PSA mRNA presence in patients with PSA protein-positive tissues (benign and malignant) but not in patients with PSA protein-negative tissues. Our data suggest that PSA is expressed frequently by normal breast tissue, by tissue of benign breast diseases, and by breast cancer tissue. Highest expression is seen in benign breast disease and lowest expression in advanced stage cancerous tissue. As PSA production is mediated by steroid hormones and their receptors, we propose that PSA may be a new marker of steroid hormone action in the normal or diseased female breast. The role of this enzyme in the development of breast diseases including breast cancer is currently unknown.",
keywords = "Benign breast disease, Breast cancer, Fibroadenomas, Prostate specific antigen, Steroid hormone receptors, Steroid hormones",
author = "He Yu and Diamandis, {Eleftherios P.} and Michael Levesque and Maurizia Giai and Riccardo Roagna and Riccardo Ponzone and Piero Sismondi and Maria Monne and Croce, {Carlo M.}",
year = "1996",
language = "English",
volume = "40",
pages = "171--178",
journal = "Breast Cancer Research and Treatment",
issn = "0167-6806",
publisher = "Springer New York LLC",
number = "2",

}

TY - JOUR

T1 - Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue

AU - Yu, He

AU - Diamandis, Eleftherios P.

AU - Levesque, Michael

AU - Giai, Maurizia

AU - Roagna, Riccardo

AU - Ponzone, Riccardo

AU - Sismondi, Piero

AU - Monne, Maria

AU - Croce, Carlo M.

PY - 1996

Y1 - 1996

N2 - Prostate specific antigen (PSA) is a tumor marker used widely for the diagnosis and monitoring of prostatic adenocarcinoma. Recently, we provided evidence that PSA may also be produced by breast tumors. In this report we examined quantitatively the PSA levels in 199 breast tumors, 48 tissues with benign breast disease (BBD, 34 fibroadenomas), and 36 normal breast tissues. Significant amounts of PSA (≤ 0.030 ng of PSA per mg of total protein) were found in 28% of breast tumors, 65% of BBD tissues, and 33% of normal breast tissues. PSA positivity in breast tumors was highest in stage I disease (34%) and decreased with disease stage (24% in stage II and 18% in stage III-IV). Using polymerase chain reaction amplification we have shown PSA mRNA presence in patients with PSA protein-positive tissues (benign and malignant) but not in patients with PSA protein-negative tissues. Our data suggest that PSA is expressed frequently by normal breast tissue, by tissue of benign breast diseases, and by breast cancer tissue. Highest expression is seen in benign breast disease and lowest expression in advanced stage cancerous tissue. As PSA production is mediated by steroid hormones and their receptors, we propose that PSA may be a new marker of steroid hormone action in the normal or diseased female breast. The role of this enzyme in the development of breast diseases including breast cancer is currently unknown.

AB - Prostate specific antigen (PSA) is a tumor marker used widely for the diagnosis and monitoring of prostatic adenocarcinoma. Recently, we provided evidence that PSA may also be produced by breast tumors. In this report we examined quantitatively the PSA levels in 199 breast tumors, 48 tissues with benign breast disease (BBD, 34 fibroadenomas), and 36 normal breast tissues. Significant amounts of PSA (≤ 0.030 ng of PSA per mg of total protein) were found in 28% of breast tumors, 65% of BBD tissues, and 33% of normal breast tissues. PSA positivity in breast tumors was highest in stage I disease (34%) and decreased with disease stage (24% in stage II and 18% in stage III-IV). Using polymerase chain reaction amplification we have shown PSA mRNA presence in patients with PSA protein-positive tissues (benign and malignant) but not in patients with PSA protein-negative tissues. Our data suggest that PSA is expressed frequently by normal breast tissue, by tissue of benign breast diseases, and by breast cancer tissue. Highest expression is seen in benign breast disease and lowest expression in advanced stage cancerous tissue. As PSA production is mediated by steroid hormones and their receptors, we propose that PSA may be a new marker of steroid hormone action in the normal or diseased female breast. The role of this enzyme in the development of breast diseases including breast cancer is currently unknown.

KW - Benign breast disease

KW - Breast cancer

KW - Fibroadenomas

KW - Prostate specific antigen

KW - Steroid hormone receptors

KW - Steroid hormones

UR - http://www.scopus.com/inward/record.url?scp=0029789295&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029789295&partnerID=8YFLogxK

M3 - Article

VL - 40

SP - 171

EP - 178

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 2

ER -