Abstract
Prostate specific antigen (PSA) is a tumor marker used widely for the diagnosis and monitoring of prostatic adenocarcinoma. Recently, we provided evidence that PSA may also be produced by breast tumors. In this report we examined quantitatively the PSA levels in 199 breast tumors, 48 tissues with benign breast disease (BBD, 34 fibroadenomas), and 36 normal breast tissues. Significant amounts of PSA (≤ 0.030 ng of PSA per mg of total protein) were found in 28% of breast tumors, 65% of BBD tissues, and 33% of normal breast tissues. PSA positivity in breast tumors was highest in stage I disease (34%) and decreased with disease stage (24% in stage II and 18% in stage III-IV). Using polymerase chain reaction amplification we have shown PSA mRNA presence in patients with PSA protein-positive tissues (benign and malignant) but not in patients with PSA protein-negative tissues. Our data suggest that PSA is expressed frequently by normal breast tissue, by tissue of benign breast diseases, and by breast cancer tissue. Highest expression is seen in benign breast disease and lowest expression in advanced stage cancerous tissue. As PSA production is mediated by steroid hormones and their receptors, we propose that PSA may be a new marker of steroid hormone action in the normal or diseased female breast. The role of this enzyme in the development of breast diseases including breast cancer is currently unknown.
| Original language | English |
|---|---|
| Pages (from-to) | 171-178 |
| Number of pages | 8 |
| Journal | Breast Cancer Research and Treatment |
| Volume | 40 |
| Issue number | 2 |
| Publication status | Published - 1996 |
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Keywords
- Benign breast disease
- Breast cancer
- Fibroadenomas
- Prostate specific antigen
- Steroid hormone receptors
- Steroid hormones
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue. / Yu, He; Diamandis, Eleftherios P.; Levesque, Michael; Giai, Maurizia; Roagna, Riccardo; Ponzone, Riccardo; Sismondi, Piero; Monne, Maria; Croce, Carlo M.
In: Breast Cancer Research and Treatment, Vol. 40, No. 2, 1996, p. 171-178.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue
AU - Yu, He
AU - Diamandis, Eleftherios P.
AU - Levesque, Michael
AU - Giai, Maurizia
AU - Roagna, Riccardo
AU - Ponzone, Riccardo
AU - Sismondi, Piero
AU - Monne, Maria
AU - Croce, Carlo M.
PY - 1996
Y1 - 1996
N2 - Prostate specific antigen (PSA) is a tumor marker used widely for the diagnosis and monitoring of prostatic adenocarcinoma. Recently, we provided evidence that PSA may also be produced by breast tumors. In this report we examined quantitatively the PSA levels in 199 breast tumors, 48 tissues with benign breast disease (BBD, 34 fibroadenomas), and 36 normal breast tissues. Significant amounts of PSA (≤ 0.030 ng of PSA per mg of total protein) were found in 28% of breast tumors, 65% of BBD tissues, and 33% of normal breast tissues. PSA positivity in breast tumors was highest in stage I disease (34%) and decreased with disease stage (24% in stage II and 18% in stage III-IV). Using polymerase chain reaction amplification we have shown PSA mRNA presence in patients with PSA protein-positive tissues (benign and malignant) but not in patients with PSA protein-negative tissues. Our data suggest that PSA is expressed frequently by normal breast tissue, by tissue of benign breast diseases, and by breast cancer tissue. Highest expression is seen in benign breast disease and lowest expression in advanced stage cancerous tissue. As PSA production is mediated by steroid hormones and their receptors, we propose that PSA may be a new marker of steroid hormone action in the normal or diseased female breast. The role of this enzyme in the development of breast diseases including breast cancer is currently unknown.
AB - Prostate specific antigen (PSA) is a tumor marker used widely for the diagnosis and monitoring of prostatic adenocarcinoma. Recently, we provided evidence that PSA may also be produced by breast tumors. In this report we examined quantitatively the PSA levels in 199 breast tumors, 48 tissues with benign breast disease (BBD, 34 fibroadenomas), and 36 normal breast tissues. Significant amounts of PSA (≤ 0.030 ng of PSA per mg of total protein) were found in 28% of breast tumors, 65% of BBD tissues, and 33% of normal breast tissues. PSA positivity in breast tumors was highest in stage I disease (34%) and decreased with disease stage (24% in stage II and 18% in stage III-IV). Using polymerase chain reaction amplification we have shown PSA mRNA presence in patients with PSA protein-positive tissues (benign and malignant) but not in patients with PSA protein-negative tissues. Our data suggest that PSA is expressed frequently by normal breast tissue, by tissue of benign breast diseases, and by breast cancer tissue. Highest expression is seen in benign breast disease and lowest expression in advanced stage cancerous tissue. As PSA production is mediated by steroid hormones and their receptors, we propose that PSA may be a new marker of steroid hormone action in the normal or diseased female breast. The role of this enzyme in the development of breast diseases including breast cancer is currently unknown.
KW - Benign breast disease
KW - Breast cancer
KW - Fibroadenomas
KW - Prostate specific antigen
KW - Steroid hormone receptors
KW - Steroid hormones
UR - http://www.scopus.com/inward/record.url?scp=0029789295&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029789295&partnerID=8YFLogxK
M3 - Article
VL - 40
SP - 171
EP - 178
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 2
ER -