TY - JOUR
T1 - Prostate volume and adverse prostate cancer features
T2 - Fact not artifact
AU - Briganti, Alberto
AU - Chun, Felix K H
AU - Suardi, Nazareno
AU - Gallina, Andrea
AU - Walz, Jochen
AU - Graefen, Markus
AU - Shariat, Shahrokh
AU - Ebersdobler, Andreas
AU - Rigatti, Patrizio
AU - Perrotte, Paul
AU - Saad, Fred
AU - Montorsi, Francesco
AU - Huland, Hartwig
AU - Karakiewicz, Pierre I.
PY - 2007/12
Y1 - 2007/12
N2 - Purpose: A recent prostate cancer finasteride chemoprevention trial showed a higher rate of sextant biopsy-detected high grade prostate cancer (HGPCa) in finasteride exposed men, whose prostates were significantly smaller than those of controls. We investigated the association between prostate size and prostate cancer grade and stage in a large (n = 3412) single center radical prostatectomy cohort, which was unexposed to any form of hormonal manipulation. Methods: Logistic regression models were used. Results: Small prostates were associated with higher rate of HGPCa at biopsy and at radical prostatectomy (both p <0.001), with higher rate of extracapsular extension (p <0.001), seminal vesicle invasion (p <0.001) and with tumor volume >3.4cc, after accounting for age, PSA, clinical stage and year of surgery. Conclusions: Our findings demonstrate that prostate cancers located in small glands are fundamentally more aggressive than those located within larger glands. In consequence, prostate cancer detection and treatment strategies should account for prostate volume.
AB - Purpose: A recent prostate cancer finasteride chemoprevention trial showed a higher rate of sextant biopsy-detected high grade prostate cancer (HGPCa) in finasteride exposed men, whose prostates were significantly smaller than those of controls. We investigated the association between prostate size and prostate cancer grade and stage in a large (n = 3412) single center radical prostatectomy cohort, which was unexposed to any form of hormonal manipulation. Methods: Logistic regression models were used. Results: Small prostates were associated with higher rate of HGPCa at biopsy and at radical prostatectomy (both p <0.001), with higher rate of extracapsular extension (p <0.001), seminal vesicle invasion (p <0.001) and with tumor volume >3.4cc, after accounting for age, PSA, clinical stage and year of surgery. Conclusions: Our findings demonstrate that prostate cancers located in small glands are fundamentally more aggressive than those located within larger glands. In consequence, prostate cancer detection and treatment strategies should account for prostate volume.
KW - High grade prostate cancer
KW - Prostate cancer
KW - Prostate volume
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U2 - 10.1016/j.ejca.2007.09.022
DO - 10.1016/j.ejca.2007.09.022
M3 - Article
C2 - 17996442
AN - SCOPUS:36349014841
VL - 43
SP - 2669
EP - 2677
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
IS - 18
ER -