Prostatic metastases from testicular nonseminomatous germ cell cancer

Two case reports and a review of the literature

Research output: Contribution to journalArticle

Abstract

Background. Prostatic metastases from testicular germ cell tumors (TGCTs) are extremely uncommon. To the best of our knowledge, only five cases of prostatic metastases from seminoma have been reported in the literature. Conversely, no cases of metastases to the prostate from nonseminomatous germ cell tumors (NSGCT) have been previously reported. Case presentation. We present two patients who developed prostatic metastases 5 and 21 years after the initial diagnosis. The first case concerned a 28-year-old Caucasian man who underwent a right orchiectomy and right retroperitoneal lymph node dissection (RPLND) for a stage I NSGCT in 1999 and five years later was diagnosed with prostatic metastases. The second case concerned a 30-year-old man treated with a right orchiectomy and right RPLND for stage I NSGCT in 1985 who was diagnosed with prostatic metastases in 2006, 21 years after primary surgery. We reviewed the available literature on the topic. Conclusion. Prostatic metastases from TCGTs are highly unusual. Lower urinary tract symptoms in patients treated for previous testicular cancer require immediate clinical attention. However, because of their extreme rarity, specific clinical investigations to screen for possible prostatic involvement from TGCT should not be recommended.

Original languageEnglish
JournalTumori
Volume99
Issue number5
DOIs
Publication statusPublished - Sep 2013

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Germ Cell and Embryonal Neoplasms
Neoplasm Metastasis
Orchiectomy
Lymph Node Excision
Lower Urinary Tract Symptoms
Seminoma
Testicular Neoplasms
Prostate
Nonseminomatous germ cell tumor

Keywords

  • Metastases
  • Nonseminomatous germ cell tumor
  • Prostate
  • Testicular cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

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title = "Prostatic metastases from testicular nonseminomatous germ cell cancer: Two case reports and a review of the literature",
abstract = "Background. Prostatic metastases from testicular germ cell tumors (TGCTs) are extremely uncommon. To the best of our knowledge, only five cases of prostatic metastases from seminoma have been reported in the literature. Conversely, no cases of metastases to the prostate from nonseminomatous germ cell tumors (NSGCT) have been previously reported. Case presentation. We present two patients who developed prostatic metastases 5 and 21 years after the initial diagnosis. The first case concerned a 28-year-old Caucasian man who underwent a right orchiectomy and right retroperitoneal lymph node dissection (RPLND) for a stage I NSGCT in 1999 and five years later was diagnosed with prostatic metastases. The second case concerned a 30-year-old man treated with a right orchiectomy and right RPLND for stage I NSGCT in 1985 who was diagnosed with prostatic metastases in 2006, 21 years after primary surgery. We reviewed the available literature on the topic. Conclusion. Prostatic metastases from TCGTs are highly unusual. Lower urinary tract symptoms in patients treated for previous testicular cancer require immediate clinical attention. However, because of their extreme rarity, specific clinical investigations to screen for possible prostatic involvement from TGCT should not be recommended.",
keywords = "Metastases, Nonseminomatous germ cell tumor, Prostate, Testicular cancer",
author = "Tullio Torelli and Giovanni Lughezzani and Mario Catanzaro and Nicola Nicolai and Maurizio Colecchia and Davide Biasoni and Luigi Piva and Massimo Maffezzini and Silvia Stagni and Andrea Necchi and Patrizia Giannatempo and Elena Far{\`e} and Roberto Salvioni",
year = "2013",
month = "9",
doi = "10.1700/1377.15315",
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T1 - Prostatic metastases from testicular nonseminomatous germ cell cancer

T2 - Two case reports and a review of the literature

AU - Torelli, Tullio

AU - Lughezzani, Giovanni

AU - Catanzaro, Mario

AU - Nicolai, Nicola

AU - Colecchia, Maurizio

AU - Biasoni, Davide

AU - Piva, Luigi

AU - Maffezzini, Massimo

AU - Stagni, Silvia

AU - Necchi, Andrea

AU - Giannatempo, Patrizia

AU - Farè, Elena

AU - Salvioni, Roberto

PY - 2013/9

Y1 - 2013/9

N2 - Background. Prostatic metastases from testicular germ cell tumors (TGCTs) are extremely uncommon. To the best of our knowledge, only five cases of prostatic metastases from seminoma have been reported in the literature. Conversely, no cases of metastases to the prostate from nonseminomatous germ cell tumors (NSGCT) have been previously reported. Case presentation. We present two patients who developed prostatic metastases 5 and 21 years after the initial diagnosis. The first case concerned a 28-year-old Caucasian man who underwent a right orchiectomy and right retroperitoneal lymph node dissection (RPLND) for a stage I NSGCT in 1999 and five years later was diagnosed with prostatic metastases. The second case concerned a 30-year-old man treated with a right orchiectomy and right RPLND for stage I NSGCT in 1985 who was diagnosed with prostatic metastases in 2006, 21 years after primary surgery. We reviewed the available literature on the topic. Conclusion. Prostatic metastases from TCGTs are highly unusual. Lower urinary tract symptoms in patients treated for previous testicular cancer require immediate clinical attention. However, because of their extreme rarity, specific clinical investigations to screen for possible prostatic involvement from TGCT should not be recommended.

AB - Background. Prostatic metastases from testicular germ cell tumors (TGCTs) are extremely uncommon. To the best of our knowledge, only five cases of prostatic metastases from seminoma have been reported in the literature. Conversely, no cases of metastases to the prostate from nonseminomatous germ cell tumors (NSGCT) have been previously reported. Case presentation. We present two patients who developed prostatic metastases 5 and 21 years after the initial diagnosis. The first case concerned a 28-year-old Caucasian man who underwent a right orchiectomy and right retroperitoneal lymph node dissection (RPLND) for a stage I NSGCT in 1999 and five years later was diagnosed with prostatic metastases. The second case concerned a 30-year-old man treated with a right orchiectomy and right RPLND for stage I NSGCT in 1985 who was diagnosed with prostatic metastases in 2006, 21 years after primary surgery. We reviewed the available literature on the topic. Conclusion. Prostatic metastases from TCGTs are highly unusual. Lower urinary tract symptoms in patients treated for previous testicular cancer require immediate clinical attention. However, because of their extreme rarity, specific clinical investigations to screen for possible prostatic involvement from TGCT should not be recommended.

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KW - Nonseminomatous germ cell tumor

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KW - Testicular cancer

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