TY - JOUR
T1 - Prostatic stromal tumor with fatal outcome in a young man
T2 - Histopathological and immunohistochemical case presentation
AU - Colombo, Piergiuseppe
AU - Ceresoli, Giovanni Luca
AU - Boiocchi, Leonardo
AU - Taverna, Gianluigi
AU - Grizzi, Fabio
AU - Bertuzzi, Alexia
AU - Santoro, Armando
AU - Roncalli, Massimo
PY - 2010
Y1 - 2010
N2 - Stromal tumors of the prostate are rare and only a few cases have been described in the literature, including exceptional cases of stromal tumors with unknown malignant potential (STUMP) and a fatal outcome in young patients. Morphologically distinguishing a STUMP from a stromal sarcoma of the prostate (PSS) is still a challenge. We describe the histopathological and immunohistochemical findings in a 34-year-old man with a malignant specialized cell stromal tumor of the prostate that was diagnosed initially as STUMP, and he developed lung metastases within a few months. The patient attended our hospital because of lower urinary tract symptoms, after having excreted tissue through the urethra a few months before. Ultrasonography and urethrocystoscopy examinations showed a mass arising from the verumontanum, and a transurethral resection (TUR) revealed a highgrade spindle cell sarcoma reminiscent of a phyllode tumor of the breast. The tumor cells were immunoreactive for vimentin, progesterone receptor and, focally, CD34. The preliminary histo logical findings were subsequently confirmed after radical prostatectomy. The patient developed bilateral lung metastases and died 25 months after the initial diagnosis. Although rare in young patients, the challenging differential diagnosis of STUMP and PSS means that a prostate STUMP diagnosis made on the basis of biopsy or TUR specimens also requires urethrocystoscopic monitoring for the early detection of any progression to PSS. Radical prostatectomy should also be carefully considered.
AB - Stromal tumors of the prostate are rare and only a few cases have been described in the literature, including exceptional cases of stromal tumors with unknown malignant potential (STUMP) and a fatal outcome in young patients. Morphologically distinguishing a STUMP from a stromal sarcoma of the prostate (PSS) is still a challenge. We describe the histopathological and immunohistochemical findings in a 34-year-old man with a malignant specialized cell stromal tumor of the prostate that was diagnosed initially as STUMP, and he developed lung metastases within a few months. The patient attended our hospital because of lower urinary tract symptoms, after having excreted tissue through the urethra a few months before. Ultrasonography and urethrocystoscopy examinations showed a mass arising from the verumontanum, and a transurethral resection (TUR) revealed a highgrade spindle cell sarcoma reminiscent of a phyllode tumor of the breast. The tumor cells were immunoreactive for vimentin, progesterone receptor and, focally, CD34. The preliminary histo logical findings were subsequently confirmed after radical prostatectomy. The patient developed bilateral lung metastases and died 25 months after the initial diagnosis. Although rare in young patients, the challenging differential diagnosis of STUMP and PSS means that a prostate STUMP diagnosis made on the basis of biopsy or TUR specimens also requires urethrocystoscopic monitoring for the early detection of any progression to PSS. Radical prostatectomy should also be carefully considered.
KW - Mesenchymal tumor
KW - Prostatic neoplasm
KW - Stromal sarcoma
KW - Stromal tumor
KW - Stromal tumors with unknown malignant potential
UR - http://www.scopus.com/inward/record.url?scp=78249255834&partnerID=8YFLogxK
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U2 - 10.4081/rt.2010.e57
DO - 10.4081/rt.2010.e57
M3 - Article
C2 - 21234249
AN - SCOPUS:78249255834
VL - 2
SP - 163
EP - 166
JO - Rare Tumors
JF - Rare Tumors
SN - 2036-3605
IS - 4
ER -