ProstaTrend—A Multivariable Prognostic RNA Expression Score for Aggressive Prostate Cancer

Markus Kreuz, Dominik J. Otto, Susanne Fuessel, Conny Blumert, Catharina Bertram, Sophie Bartsch, Dennis Loeffler, Sven Holger Puppel, Michael Rade, Tilo Buschmann, Sabina Christ, Kati Erdmann, Maik Friedrich, Michael Froehner, Michael H. Muders, Stephan Schreiber, Michael Specht, Marieta I. Toma, Fabio Benigni, Massimo FreschiGiorgio Gandaglia, Alberto Briganti, Gustavo B. Baretton, Markus Loeffler, Jörg Hackermüller, Kristin Reiche, Manfred Wirth, Friedemann Horn

Research output: Contribution to journalArticlepeer-review

Abstract

We developed a multigene expression score ProstaTrend based on transcriptome-wide next-generation sequencing. ProstaTrend outperforms current methods for long-term prognosis of prostate cancer and allows counseling of patients after radical prostatectomy regarding whether adjuvant treatment should be considered.

Original languageEnglish
Pages (from-to)452-459
Number of pages8
JournalEuropean Urology
Volume78
Issue number3
DOIs
Publication statusPublished - Sep 2020

Keywords

  • Biomarker
  • Molecular diagnostic testing
  • Molecular pathology
  • Next-generation sequencing
  • Personalized medicine
  • Prostate cancer
  • Transcriptome

ASJC Scopus subject areas

  • Urology

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