Prosthetic joint infection due to Mycobacterium xenopi: a review of the literature with a new case report

Research output: Contribution to journalReview article

Abstract

Purpose: Extrapulmonary infections due to M. xenopi, particularly osteoarticular localizations, are rare. The purpose of this paper is to describe a case of prosthetic hip infection and to review the published literature on cases of M. xenopi osteoarticular infections. Methods: Literature search was performed in the following databases: MEDLINE (PubMed), Embase, Central (the Cochrane Library 2019, Issue 1), LILACS (BIREME) (Latin American and Caribbean Health Science Information database) and Clinical Trials databases (14th August 2018). We included all case reports and case series on adult patients diagnosed with bone or joint infection by M. xenopi for whom the treatment and outcome were specified. Results: We retrieved 30 cases published between 1982 and 2012, among which 25 (83.3%) were reported from Europe. The two most common infection sites were spine (12/30, 40%) and knee (9/30, 30%). Risk factors for infection were previous invasive procedures (11/30, 36.7%), autoimmune disease (8/30, 26.7%), AIDS (4/30, 13.3%) and other comorbidities (2/30, 6.7%); five patients had no past medical history. All patients were treated with antibiotic combinations, but composition and duration of regimens hugely varied. Surgical intervention was performed in 16 patients (53.3%). Only 11 patients obtained full recovery of articular mobility after treatment. Conclusion: This work highlights the difficulties in diagnosing and treating M. xenopi osteoarticular infections. Globally, evidence supporting the best practice for diagnosis and treatment of this infection is scanty.

Original languageEnglish
JournalInfection
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Mycobacterium xenopi
Joints
Infection
Databases
Information Science
Practice Guidelines
PubMed
MEDLINE
Autoimmune Diseases
Libraries
Comorbidity
Hip
Knee
Acquired Immunodeficiency Syndrome
Spine
Clinical Trials
Anti-Bacterial Agents

Keywords

  • Mycobacterium xenopi
  • Osteoarticular infection
  • Osteomyelitis
  • Prosthetic joint infection
  • Review

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

@article{0b50cedb221d437291ab76bc10f2cf05,
title = "Prosthetic joint infection due to Mycobacterium xenopi: a review of the literature with a new case report",
abstract = "Purpose: Extrapulmonary infections due to M. xenopi, particularly osteoarticular localizations, are rare. The purpose of this paper is to describe a case of prosthetic hip infection and to review the published literature on cases of M. xenopi osteoarticular infections. Methods: Literature search was performed in the following databases: MEDLINE (PubMed), Embase, Central (the Cochrane Library 2019, Issue 1), LILACS (BIREME) (Latin American and Caribbean Health Science Information database) and Clinical Trials databases (14th August 2018). We included all case reports and case series on adult patients diagnosed with bone or joint infection by M. xenopi for whom the treatment and outcome were specified. Results: We retrieved 30 cases published between 1982 and 2012, among which 25 (83.3{\%}) were reported from Europe. The two most common infection sites were spine (12/30, 40{\%}) and knee (9/30, 30{\%}). Risk factors for infection were previous invasive procedures (11/30, 36.7{\%}), autoimmune disease (8/30, 26.7{\%}), AIDS (4/30, 13.3{\%}) and other comorbidities (2/30, 6.7{\%}); five patients had no past medical history. All patients were treated with antibiotic combinations, but composition and duration of regimens hugely varied. Surgical intervention was performed in 16 patients (53.3{\%}). Only 11 patients obtained full recovery of articular mobility after treatment. Conclusion: This work highlights the difficulties in diagnosing and treating M. xenopi osteoarticular infections. Globally, evidence supporting the best practice for diagnosis and treatment of this infection is scanty.",
keywords = "Mycobacterium xenopi, Osteoarticular infection, Osteomyelitis, Prosthetic joint infection, Review",
author = "Paola Rodari and Stefania Marocco and Dora Buonfrate and Anna Beltrame and Chiara Piubelli and Pierantonio Orza and Fittipaldo, {Veronica Andrea} and Zeno Bisoffi",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s15010-019-01318-1",
language = "English",
journal = "Infection",
issn = "0300-8126",
publisher = "Urban und Vogel GmbH",

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TY - JOUR

T1 - Prosthetic joint infection due to Mycobacterium xenopi

T2 - a review of the literature with a new case report

AU - Rodari, Paola

AU - Marocco, Stefania

AU - Buonfrate, Dora

AU - Beltrame, Anna

AU - Piubelli, Chiara

AU - Orza, Pierantonio

AU - Fittipaldo, Veronica Andrea

AU - Bisoffi, Zeno

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: Extrapulmonary infections due to M. xenopi, particularly osteoarticular localizations, are rare. The purpose of this paper is to describe a case of prosthetic hip infection and to review the published literature on cases of M. xenopi osteoarticular infections. Methods: Literature search was performed in the following databases: MEDLINE (PubMed), Embase, Central (the Cochrane Library 2019, Issue 1), LILACS (BIREME) (Latin American and Caribbean Health Science Information database) and Clinical Trials databases (14th August 2018). We included all case reports and case series on adult patients diagnosed with bone or joint infection by M. xenopi for whom the treatment and outcome were specified. Results: We retrieved 30 cases published between 1982 and 2012, among which 25 (83.3%) were reported from Europe. The two most common infection sites were spine (12/30, 40%) and knee (9/30, 30%). Risk factors for infection were previous invasive procedures (11/30, 36.7%), autoimmune disease (8/30, 26.7%), AIDS (4/30, 13.3%) and other comorbidities (2/30, 6.7%); five patients had no past medical history. All patients were treated with antibiotic combinations, but composition and duration of regimens hugely varied. Surgical intervention was performed in 16 patients (53.3%). Only 11 patients obtained full recovery of articular mobility after treatment. Conclusion: This work highlights the difficulties in diagnosing and treating M. xenopi osteoarticular infections. Globally, evidence supporting the best practice for diagnosis and treatment of this infection is scanty.

AB - Purpose: Extrapulmonary infections due to M. xenopi, particularly osteoarticular localizations, are rare. The purpose of this paper is to describe a case of prosthetic hip infection and to review the published literature on cases of M. xenopi osteoarticular infections. Methods: Literature search was performed in the following databases: MEDLINE (PubMed), Embase, Central (the Cochrane Library 2019, Issue 1), LILACS (BIREME) (Latin American and Caribbean Health Science Information database) and Clinical Trials databases (14th August 2018). We included all case reports and case series on adult patients diagnosed with bone or joint infection by M. xenopi for whom the treatment and outcome were specified. Results: We retrieved 30 cases published between 1982 and 2012, among which 25 (83.3%) were reported from Europe. The two most common infection sites were spine (12/30, 40%) and knee (9/30, 30%). Risk factors for infection were previous invasive procedures (11/30, 36.7%), autoimmune disease (8/30, 26.7%), AIDS (4/30, 13.3%) and other comorbidities (2/30, 6.7%); five patients had no past medical history. All patients were treated with antibiotic combinations, but composition and duration of regimens hugely varied. Surgical intervention was performed in 16 patients (53.3%). Only 11 patients obtained full recovery of articular mobility after treatment. Conclusion: This work highlights the difficulties in diagnosing and treating M. xenopi osteoarticular infections. Globally, evidence supporting the best practice for diagnosis and treatment of this infection is scanty.

KW - Mycobacterium xenopi

KW - Osteoarticular infection

KW - Osteomyelitis

KW - Prosthetic joint infection

KW - Review

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JO - Infection

JF - Infection

SN - 0300-8126

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