Prosthetic valve endocarditis after transcatheter or surgical aortic valve replacement with a bioprosthesis: results from the FinnValve Registry

Noriaki Moriyama, Teemu Laakso, Fausto Biancari, Peter Raivio, Maina P. Jalava, Jussi Jaakkola, Sebastian Dahlbacka, Eeva-Maija Kinnunen, Tatu Juvonen, Annastiina Husso, Matti Niemela, Tuomas Ahvenvaara, Tuomas Tauriainen, Marko Virtanen, Pasi Maaranen, Markku Eskola, Stefano Rosato, Timo Makikallio, Mikko Savontaus, Antti ValtolaVesa Anttila, Juhani Airaksinen, Mika Laine

Research output: Contribution to journalArticle

Abstract

Aims: The aim of this study was to compare the risk of prosthetic valve endocarditis (PVE) in patients with transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR). Methods and results: The FinnValve registry included data from 6,463 consecutive patients who underwent TAVR (n=2,130) or SAVR (n=4,333) with a bioprosthesis from 2008 to 2017. PVE was defined according to the modified Duke criteria. In this study, the incidence of PVE was 3.4/1,000 person-years after TAVR, and 2.9/1,000 person-years after SAVR. In competing risk analysis there was no significant difference in the risk of PVE between patients with TAVR and SAVR over an eight-year observational period. Male gender (HR 1.73, 95 1.04-2.89) and deep sternal wound infection or vascular access-site infection (HR 5.45, 95 2.24-13.2) were positively associated with PVE, but not type of procedure (HR 1.09, 95 0.59-2.01) in multivariate analysis. The mortality rate was 37.72.5hospital mortality (HR 0.34, 95 0.21-0.61). Conclusions: PVE is rare, and its risk is similar after TAVR and SAVR.
Original languageEnglish
Pages (from-to)E499+
JournalEuroIntervention
Volume15
Issue number6
DOIs
Publication statusPublished - Aug 1 2019

Keywords

  • Prosthetic valve
  • endcarditis
  • TAVI
  • surgical valve replacement
  • bioprosthesis

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    Moriyama, N., Laakso, T., Biancari, F., Raivio, P., Jalava, M. P., Jaakkola, J., Dahlbacka, S., Kinnunen, E-M., Juvonen, T., Husso, A., Niemela, M., Ahvenvaara, T., Tauriainen, T., Virtanen, M., Maaranen, P., Eskola, M., Rosato, S., Makikallio, T., Savontaus, M., ... Laine, M. (2019). Prosthetic valve endocarditis after transcatheter or surgical aortic valve replacement with a bioprosthesis: results from the FinnValve Registry. EuroIntervention, 15(6), E499+. https://doi.org/10.4244/EIJ-D-19-00247