Protease-antiprotease imbalance: Local evaluation with bronchoalveolar lavage

M. Luisetti; P. D. Piccioni; A. M. Donnetta; A. Bulgheroni; V. Peona

doi:10.1159/000196099

Protease-antiprotease imbalance: Local evaluation with bronchoalveolar lavage

M. Luisetti, P. D. Piccioni, A. M. Donnetta, A. Bulgheroni, V. Peona

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

The protease-antiprotease imbalance is thought to be involved in a variety of destructive lung diseases: pulmonary emphysema, chronic bronchitis, cystic fibrosis and adult respiratory distress syndrome. Bronchoalveolar lavage allowed the investigators to assess the protease-antiprotease shift in such conditions but sometimes gave conflicting results. The role of bronchoalveolar lavage as a research and diagnostic tool in diseases characterised by protease-anti-protease imbalance is reviewed, as well as its potential usefulness in the near future.

Original language	English
Pages (from-to)	24-27
Number of pages	4
Journal	Respiration
Volume	59
DOIs	https://doi.org/10.1159/000196099
Publication status	Published - 1992

Keywords

Adult respiratory distress syndrome
Alpha-1 proteinase inhibitor
Alpha-2 macroglobulin
Antileukoprotease
Cathepsin G
Chronic bronchitis
Neutrophil elastase
Pulmonary emphysema
Sputum sol-phase

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Physiology

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10.1159/000196099

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title = "Protease-antiprotease imbalance: Local evaluation with bronchoalveolar lavage",

abstract = "The protease-antiprotease imbalance is thought to be involved in a variety of destructive lung diseases: pulmonary emphysema, chronic bronchitis, cystic fibrosis and adult respiratory distress syndrome. Bronchoalveolar lavage allowed the investigators to assess the protease-antiprotease shift in such conditions but sometimes gave conflicting results. The role of bronchoalveolar lavage as a research and diagnostic tool in diseases characterised by protease-anti-protease imbalance is reviewed, as well as its potential usefulness in the near future.",

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doi = "10.1159/000196099",

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T2 - Local evaluation with bronchoalveolar lavage

AU - Luisetti, M.

AU - Piccioni, P. D.

AU - Donnetta, A. M.

AU - Bulgheroni, A.

AU - Peona, V.

PY - 1992

Y1 - 1992

N2 - The protease-antiprotease imbalance is thought to be involved in a variety of destructive lung diseases: pulmonary emphysema, chronic bronchitis, cystic fibrosis and adult respiratory distress syndrome. Bronchoalveolar lavage allowed the investigators to assess the protease-antiprotease shift in such conditions but sometimes gave conflicting results. The role of bronchoalveolar lavage as a research and diagnostic tool in diseases characterised by protease-anti-protease imbalance is reviewed, as well as its potential usefulness in the near future.

AB - The protease-antiprotease imbalance is thought to be involved in a variety of destructive lung diseases: pulmonary emphysema, chronic bronchitis, cystic fibrosis and adult respiratory distress syndrome. Bronchoalveolar lavage allowed the investigators to assess the protease-antiprotease shift in such conditions but sometimes gave conflicting results. The role of bronchoalveolar lavage as a research and diagnostic tool in diseases characterised by protease-anti-protease imbalance is reviewed, as well as its potential usefulness in the near future.

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KW - Alpha-1 proteinase inhibitor

KW - Alpha-2 macroglobulin

KW - Antileukoprotease

KW - Cathepsin G

KW - Chronic bronchitis

KW - Neutrophil elastase

KW - Pulmonary emphysema

KW - Sputum sol-phase

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Protease-antiprotease imbalance: Local evaluation with bronchoalveolar lavage

Abstract

Keywords

ASJC Scopus subject areas

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