Protease-antiprotease imbalance: Local evaluation with bronchoalveolar lavage

M. Luisetti, P. D. Piccioni, A. M. Donnetta, A. Bulgheroni, V. Peona

Research output: Contribution to journalArticlepeer-review


The protease-antiprotease imbalance is thought to be involved in a variety of destructive lung diseases: pulmonary emphysema, chronic bronchitis, cystic fibrosis and adult respiratory distress syndrome. Bronchoalveolar lavage allowed the investigators to assess the protease-antiprotease shift in such conditions but sometimes gave conflicting results. The role of bronchoalveolar lavage as a research and diagnostic tool in diseases characterised by protease-anti-protease imbalance is reviewed, as well as its potential usefulness in the near future.

Original languageEnglish
Pages (from-to)24-27
Number of pages4
Publication statusPublished - 1992


  • Adult respiratory distress syndrome
  • Alpha-1 proteinase inhibitor
  • Alpha-2 macroglobulin
  • Antileukoprotease
  • Cathepsin G
  • Chronic bronchitis
  • Neutrophil elastase
  • Pulmonary emphysema
  • Sputum sol-phase

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology


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