Protease resistant prion proteins are not present in sporadic 'poor outcome' schizophrenia

S. E. Arnold, J. Q. Trojanowski, P. Parchi

Research output: Contribution to journalArticlepeer-review


Various clinical and epidemiological data have suggested the possibility of infectious mechanisms in schizophrenia. In addition, lengthy prodromal psychiatric symptoms can presage the development of Creutzfeldt-Jakob disease, a prototypical prion disorder. Accordingly, the presence of human protease resistant prion proteins (PrP(res)) was assessed in postmortem frontal cortical and thalamic tissues from a prospectively accrued and well characterised sample of elderly patients with chronic, sporadic, 'poor outcome' schizophrenia using a sensitive immunoblot assay. No PrP(res) was found in the brains of any of the cases, providing evidence against a role for abnormal prion proteins in the pathogenesis of schizophrenia.

Original languageEnglish
Pages (from-to)90-92
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number1
Publication statusPublished - 1999


  • Creutzfeldt-Jakob disease
  • Prion protein
  • Schizophrenia

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health


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