Proteases Upregulation in Sporadic Alzheimer's Disease Brain

Alessandro Medoro, Silvia Bartollino, Donatella Mignogna, Nicola Marziliano, Carola Porcile, Mario Nizzari, Tullio Florio, Aldo Pagano, Gennaro Raimo, Mariano Intrieri, Claudio Russo

Research output: Contribution to journalArticle

Abstract

Certain proteases are involved in Alzheimer's disease (AD) and their erroneous control may contribute to the pathology onset and progression. In this study we evaluated the cerebral expression of eight proteases, involved in both AβPP processing and extracellular matrix remodeling. Among these proteases, ADAM10, ADAMTS1, Cathepsin D, and Meprin β show a significantly higher mRNAs expression in sporadic AD subjects versus controls, while ADAMTS1, Cathepsin D, and Meprin β show an increment also at the protein level. These data indicate that transcriptional events affecting brain proteases are activated in AD patients, suggesting a link between proteolysis and AD.

Original languageEnglish
Pages (from-to)931-938
Number of pages8
JournalJournal of Alzheimer's Disease
Volume68
Issue number3
DOIs
Publication statusPublished - Jan 1 2019

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Keywords

  • -secretase
  • ADAMTS1
  • Alzheimer's disease
  • cancer
  • Cathepsin D
  • Meprin β
  • RT-PCR
  • western blot

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Medoro, A., Bartollino, S., Mignogna, D., Marziliano, N., Porcile, C., Nizzari, M., Florio, T., Pagano, A., Raimo, G., Intrieri, M., & Russo, C. (2019). Proteases Upregulation in Sporadic Alzheimer's Disease Brain. Journal of Alzheimer's Disease, 68(3), 931-938. https://doi.org/10.3233/JAD-181284