Protecting cognition from aging and Alzheimer's disease: A computerized cognitive training combined with reminiscence therapy

Francesco Barban, Roberta Annicchiarico, Stelios Pantelopoulos, Alessia Federici, Roberta Perri, Lucia Fadda, Giovanni Augusto Carlesimo, Claudia Ricci, Simone Giuli, Francesco Scalici, Chiara Stella Turchetta, Fulvia Adriano, Maria Giovanna Lombardi, Chiara Zaccarelli, Giulio Cirillo, Simone Passuti, Paolo Mattarelli, Olga Lymperopoulou, Paraskevi Sakka, Eva NtanasiReyes Moliner, Azucena Garcia-Palacios, Carlo Caltagirone

Research output: Contribution to journalArticle

Abstract

Objective The aim of this paper was to assess the efficacy of process-based cognitive training (pb-CT) combined with reminiscence therapy (RT) in patients with mild Alzheimer's disease (mAD) and mild cognitive impairment (MCI) and in healthy elderly (HE) subjects. Methods This multicenter, randomized, controlled trial involved 348 participants with mAD, MCI, and HE from four European countries. Participants were randomly assigned to two arms of a crossover design: those in arm A underwent 3 months of computerized pb-CT for memory and executive functions combined with RT and 3 months of rest; those in arm B underwent the reverse. The primary outcome was the effect of the training on memory and executive functions performance. The secondary outcome was the effect of the training on functional abilities in mAD assessed with the instrumental activities of daily living. Results We found a significant effect of the training for memory in all three groups on delayed recall of the Rey Auditory Verbal Learning Test and for executive functions in HE on the phonological fluency test. MCI and HE participants maintained these effects at follow-up. MCI and mAD participants also showed a significant effect of the training on the Mini-mental state examination scale. Participants with mAD showed more stable instrumental activities of daily living during the training versus the rest period. Conclusions Our results corroborate the positive effect of pb-CT and its maintenance primarily on memory in HE and MCI participants that did not seem to be potentiated by RT. Moreover, our results are very promising for the mAD participants.

Original languageEnglish
Pages (from-to)340-348
Number of pages9
JournalInternational Journal of Geriatric Psychiatry
Volume31
Issue number4
DOIs
Publication statusE-pub ahead of print - Jul 25 2015

Keywords

  • aging
  • Alzheimer's disease
  • cognitive training
  • computerized training
  • mild cognitive impairment
  • reminiscence therapy

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Protecting cognition from aging and Alzheimer's disease: A computerized cognitive training combined with reminiscence therapy'. Together they form a unique fingerprint.

  • Cite this

    Barban, F., Annicchiarico, R., Pantelopoulos, S., Federici, A., Perri, R., Fadda, L., Carlesimo, G. A., Ricci, C., Giuli, S., Scalici, F., Turchetta, C. S., Adriano, F., Lombardi, M. G., Zaccarelli, C., Cirillo, G., Passuti, S., Mattarelli, P., Lymperopoulou, O., Sakka, P., ... Caltagirone, C. (2015). Protecting cognition from aging and Alzheimer's disease: A computerized cognitive training combined with reminiscence therapy. International Journal of Geriatric Psychiatry, 31(4), 340-348. https://doi.org/10.1002/gps.4328