Minimizing ischemia during percutaneous transluminal coronary angioplasty (PTCA) may lower the risks of the procedure and enhance the short- and long-term success rates of the procedure. However we have to remember that the effects of pharmacological and mechanical interventions during PTCA may be influenced by the functional status of the myocardium. In man the myocardium supplied by a stenotic coronary artery may have a normal metabolic condition or may be stunned, hibernated or even preconditioned by previous ischemic episodes, while the procedure itself may provoke stunning or preconditioning. Many different drugs have been tested for their efficacy under this clinical setting but we recognize that the prolongation of balloon inflation time, though statistically significant, has never proved to be so large to be clinically relevant. Mechanical antegrade coronary infusion (with either blood or oxygenated fluorocarbons) offers the most reliable method for prolonged periods of myocardial protection during PTCA.
|Translated title of the contribution||Protection against ischemic damage during percutaneous coronary angioplasty|
|Number of pages||6|
|Issue number||12 Suppl 1|
|Publication status||Published - Dec 1991|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine