Protection by apomorphine in two independent models of acute inhibition of oxidative metabolism in rodents

Paola Castri, Carla Busceti, Giuseppe Battaglia, Francesca Girardi, Michele Cavallari, Francesco Orzi, Francesco Fornai

Research output: Contribution to journalArticlepeer-review

Abstract

Apomorphine was administered by continuous infusion in the mouse following acute inhibition of oxidative metabolism induced by systemic administration of MPTP, and in the gerbil following transient occlusion of the carotid arteries. The dosage employed was comparable to the one used in the treatment of severe on-off fluctuations in Parkinson's disease. The results show that apomorphine significantly diminishes the striatal lesion caused by MPTP and the size of the infarct associated with the transient global ischemia. These data suggest that apomorphine is neuroprotective, probably by means of an antioxidant effect, at doses that are clinically used. The finding may be relevant to brain ischemia as well to chronic neurodegeneration.

Original languageEnglish
Pages (from-to)387-394
Number of pages8
JournalClinical and Experimental Hypertension
Volume28
Issue number3-4
DOIs
Publication statusPublished - Jul 1 2006

Keywords

  • Apomorphine
  • Gerbil
  • Ischemia
  • Mice
  • MPTP
  • Neuroprotection
  • Oxidative metabolism

ASJC Scopus subject areas

  • Internal Medicine

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