Protection by ketotifen and disodium cromoglycate against bronchoconstriction induced by inhalation of acetylsalicylic acid

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Abstract

Ten patients with acetylsalicylic acid intolerance (decrease in FEV1 of at least 20% to the threshold dose of inhaled acetyl salicylic acid) were treated in a double-blind, double-dummy, cross-over study with ketotifen (2 x 1 mg/day, p.o.) and disodium cromoglycate (4 x 20 mg/day, by inhalation) for 3 days. On the fourth day, 2 hours after the morning dose of the drug, the patients were challenged with the same threshold dose of acetyl salicylic acid (ASA) that had been able to change respiratory function. After treatment with ketotifen and with disodium cromoglycate (DSCG), the changes in FEV1 and MEF50 after ASA were significantly smaller than before treatment. There were no significant difference in the effectiveness of the two treatments. Ketotifen completely protected 6 patients and DSCG completely protected 8 patients. Two patients were not protected by either drug.

Original languageEnglish
Pages (from-to)785-789
Number of pages5
JournalCurrent Therapeutic Research
Volume38
Issue number5
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Medicine(all)

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