Protection from inflammatory disease in insulin resistance: The role of mannan-binding lectin

J. M. Fernández-Real, M. Straczkowski, J. Vendrell, F. Soriguer, S. Pérez Del Pulgar, L. Gallart, A. López-Bermejo, I. Kowalska, M. Manco, F. Cardona, M. M. García-Gil, G. Mingrone, C. Richart, W. Ricart, A. Zorzano

Research output: Contribution to journalArticlepeer-review

Abstract

Aims/hypothesis: Decreased sensing of the innate immune system may lead to chronic activation of the inflammatory cascade. We hypothesised that mannan-binding lectin (MBL) deficiency may confer risk of obesity and insulin resistance. Materials and methods: We performed a cross-sectional study of MBL protein concentration (n=434) and MBL2 gene mutations (exon 1) (n=759) in association with obesity, markers of inflammation and insulin action (euglycaemic clamp, n=113), and a longitudinal study of MBL protein before and after weight loss in obese patients (n=10). We also studied the effects of MBL in vitro in muscle cells and circulating MBL-A (mouse equivalent of human MBL) in a mouse model. Results: Among 434 consecutive non-diabetic men, the age-adjusted serum MBL concentration was lower in obese subjects than in lean subjects (median: 959 μg/ml [interquartile range: 116.8-2,044 μg/ml] vs 1,365 [467-2,513] μg/ml; p=0.01) and was accompanied by increased serum inflammatory markers. Insulin action correlated significantly with serum MBL (r=0.49, p

Original languageEnglish
Pages (from-to)2402-2411
Number of pages10
JournalDiabetologia
Volume49
Issue number10
DOIs
Publication statusPublished - Oct 2006

Keywords

  • Cytokines
  • DNA polymorphism
  • Inflammation
  • Innate immune system
  • Insulin resistance

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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