Protection of mice against tumor growth by immunization with an oncogene-encoded growth factor

D. Talarico, M. Ittmann, A. Balsari, P. Delli-Bovi, R. S. Basch, C. Basilico

Research output: Contribution to journalArticlepeer-review

Abstract

The K-fgf/hst oncogene encodes a growth factor of the fibroblast growth factor (FGF) family that is secreted and transforms cells through a mechanism of autocrine cell proliferation. K-fgf-transformed cells are highly tumorigenic in immunocompetent allogeneic and syngeneic animals. BALB/c mice were immunized with a bacterial fusion protein consisting of a portion of the MS2 polymerase and of the human K-FGF precursor lacking only the first 4 amino acids or with a recombinant protein corresponding to the mature, secreted form of K-FGF (176 amino acids). They were then challenged with syngeneic K-fgf- or H-ras-transformed cells. Vaccinated animals exhibited a significant degree of protection against tumor induction, which was specific for K-fgf-transformed cells and correlated with the ability of the immunized mice to produce high titers of anti-K-FGF antibodies. Thus immunization with a single oncogene product can protect animals against tumor cells expressing this oncogene.

Original languageEnglish
Pages (from-to)4222-4225
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume87
Issue number11
DOIs
Publication statusPublished - 1990

Keywords

  • K-fgf oncogene
  • recombinant proteins
  • tumor prevention

ASJC Scopus subject areas

  • General
  • Genetics

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