Protective action of idebenone against excitotoxic degeneration in cultured cortical neurons

Valeria Bruno, Giuseppe Battaglia, Agata Copani, Maria Angela Sortino, Pier Luigi Canonico, Ferdinando Nicoletti

Research output: Contribution to journalArticle

Abstract

The novel free radical scavenger and electron-trapping agent, idebenone, protects cultured cortical neurons against necrotic degeneration induced by either a brief exposure to N-methyl-d-aspartate (NMDA) or a prolonged exposure to kainate. As opposed to the NMDA receptor antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine hydrogen maleate (MK801), idebenone rescued cortical neurons even when applied 30 min after the NMDA pulse, suggesting that the drug interferes with the chain of toxic reactions triggered by an excessive stimulation of excitatory amino acid receptors.

Original languageEnglish
Pages (from-to)193-196
Number of pages4
JournalNeuroscience Letters
Volume178
Issue number2
DOIs
Publication statusPublished - Sep 12 1994

Keywords

  • Cortical culture
  • Excitotoxicity
  • Free radical
  • Idebenone
  • Kainate
  • NMDA

ASJC Scopus subject areas

  • Neuroscience(all)

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