Effetto protettivo di un calcio-antagonista nei confronti della vasocostrizione renale indotta dall'endotelina nel ratto normoteso.

Translated title of the contribution: Protective effect of a calcium antagonist against renal vasoconstriction induced by endothelin in the normotensive rat

P. Madeddu, F. Pala, C. Troffa, P. Pinna Parpaglia, A. Pazzola, A. Soro, P. Manunta, G. Tonolo, M. G. Melis, M. P. Demontis

Research output: Contribution to journalArticle

Abstract

We studied the effect of nifedipine, a dihydropyridine calcium antagonist, on the hemodynamic changes induced by endothelin, in awake normotensive rats. Endothelin (0.07-1.40 nmol/kg, e.v.) caused an initial hypotensive effect, followed by long lasting hypertension. Renal blood flow was reduced immediately and still remained below basal levels, at 30 minutes after endothelin injection. Nifedipine (1 mg/kg, i.p.) significantly prevented the effect of endothelin on mean blood pressure and induced a right-ward shift in the dose response curve of renal hemodynamic changes induced by endothelin. We conclude that treatment with calcium antagonist could be very useful in all those conditions in which systemic and regional vasocostriction is provoked by endothelin.

Translated title of the contributionProtective effect of a calcium antagonist against renal vasoconstriction induced by endothelin in the normotensive rat
Original languageItalian
Pages (from-to)671-678
Number of pages8
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume66
Issue number7
Publication statusPublished - Jul 1990

ASJC Scopus subject areas

  • Medicine(all)

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