Effetto protettivo di un calcio-antagonista nei confronti della vasocostrizione renale indotta dall'endotelina nel ratto normoteso.

P. Madeddu; F. Pala; C. Troffa; P. Pinna Parpaglia; A. Pazzola; A. Soro; P. Manunta; G. Tonolo; M. G. Melis; M. P. Demontis

Effetto protettivo di un calcio-antagonista nei confronti della vasocostrizione renale indotta dall'endotelina nel ratto normoteso.

Translated title of the contribution: Protective effect of a calcium antagonist against renal vasoconstriction induced by endothelin in the normotensive rat

P. Madeddu, F. Pala, C. Troffa, P. Pinna Parpaglia, A. Pazzola, A. Soro, P. Manunta, G. Tonolo, M. G. Melis, M. P. Demontis

Research output: Contribution to journal › Article › peer-review

Abstract

We studied the effect of nifedipine, a dihydropyridine calcium antagonist, on the hemodynamic changes induced by endothelin, in awake normotensive rats. Endothelin (0.07-1.40 nmol/kg, e.v.) caused an initial hypotensive effect, followed by long lasting hypertension. Renal blood flow was reduced immediately and still remained below basal levels, at 30 minutes after endothelin injection. Nifedipine (1 mg/kg, i.p.) significantly prevented the effect of endothelin on mean blood pressure and induced a right-ward shift in the dose response curve of renal hemodynamic changes induced by endothelin. We conclude that treatment with calcium antagonist could be very useful in all those conditions in which systemic and regional vasocostriction is provoked by endothelin.

Translated title of the contribution	Protective effect of a calcium antagonist against renal vasoconstriction induced by endothelin in the normotensive rat
Original language	Italian
Pages (from-to)	671-678
Number of pages	8
Journal	Bollettino della Societa Italiana di Biologia Sperimentale
Volume	66
Issue number	7
Publication status	Published - Jul 1990

ASJC Scopus subject areas

Medicine(all)

Cite this

@article{b1de17d57d4a43b8a261b6156fa048ff,

title = "Effetto protettivo di un calcio-antagonista nei confronti della vasocostrizione renale indotta dall'endotelina nel ratto normoteso.",

abstract = "We studied the effect of nifedipine, a dihydropyridine calcium antagonist, on the hemodynamic changes induced by endothelin, in awake normotensive rats. Endothelin (0.07-1.40 nmol/kg, e.v.) caused an initial hypotensive effect, followed by long lasting hypertension. Renal blood flow was reduced immediately and still remained below basal levels, at 30 minutes after endothelin injection. Nifedipine (1 mg/kg, i.p.) significantly prevented the effect of endothelin on mean blood pressure and induced a right-ward shift in the dose response curve of renal hemodynamic changes induced by endothelin. We conclude that treatment with calcium antagonist could be very useful in all those conditions in which systemic and regional vasocostriction is provoked by endothelin.",

author = "P. Madeddu and F. Pala and C. Troffa and {Pinna Parpaglia}, P. and A. Pazzola and A. Soro and P. Manunta and G. Tonolo and Melis, {M. G.} and Demontis, {M. P.}",

year = "1990",

month = jul,

language = "Italian",

volume = "66",

pages = "671--678",

journal = "Bollettino della Societa Italiana di Biologia Sperimentale",

issn = "0037-8771",

publisher = "Casa Editrice Idelson Gnocchi",

number = "7",

}

TY - JOUR

T1 - Effetto protettivo di un calcio-antagonista nei confronti della vasocostrizione renale indotta dall'endotelina nel ratto normoteso.

AU - Madeddu, P.

AU - Pala, F.

AU - Troffa, C.

AU - Pinna Parpaglia, P.

AU - Pazzola, A.

AU - Soro, A.

AU - Manunta, P.

AU - Tonolo, G.

AU - Melis, M. G.

AU - Demontis, M. P.

PY - 1990/7

Y1 - 1990/7

N2 - We studied the effect of nifedipine, a dihydropyridine calcium antagonist, on the hemodynamic changes induced by endothelin, in awake normotensive rats. Endothelin (0.07-1.40 nmol/kg, e.v.) caused an initial hypotensive effect, followed by long lasting hypertension. Renal blood flow was reduced immediately and still remained below basal levels, at 30 minutes after endothelin injection. Nifedipine (1 mg/kg, i.p.) significantly prevented the effect of endothelin on mean blood pressure and induced a right-ward shift in the dose response curve of renal hemodynamic changes induced by endothelin. We conclude that treatment with calcium antagonist could be very useful in all those conditions in which systemic and regional vasocostriction is provoked by endothelin.

AB - We studied the effect of nifedipine, a dihydropyridine calcium antagonist, on the hemodynamic changes induced by endothelin, in awake normotensive rats. Endothelin (0.07-1.40 nmol/kg, e.v.) caused an initial hypotensive effect, followed by long lasting hypertension. Renal blood flow was reduced immediately and still remained below basal levels, at 30 minutes after endothelin injection. Nifedipine (1 mg/kg, i.p.) significantly prevented the effect of endothelin on mean blood pressure and induced a right-ward shift in the dose response curve of renal hemodynamic changes induced by endothelin. We conclude that treatment with calcium antagonist could be very useful in all those conditions in which systemic and regional vasocostriction is provoked by endothelin.

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M3 - Articolo

C2 - 2083061

AN - SCOPUS:0025463540

VL - 66

SP - 671

EP - 678

JO - Bollettino della Societa Italiana di Biologia Sperimentale

JF - Bollettino della Societa Italiana di Biologia Sperimentale

SN - 0037-8771

IS - 7

ER -

Effetto protettivo di un calcio-antagonista nei confronti della vasocostrizione renale indotta dall'endotelina nel ratto normoteso.

Abstract

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