Protective effect of acetyl-l-carnitine against oxidative stress induced by antiretroviral drugs

Roberta Ferraresi, Leonarda Troiano, Erika Roat, Elisa Nemes, Enrico Lugli, Milena Nasi, Marcello Pinti, Menotti Calvani, Maurizio Iannuccelli, Andrea Cossarizza

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Both HIV infection per se and antiretroviral drugs might contribute to oxidative stress and mitochondrial dysfunctions. In this study we assess zidovudine, stavudine and didanosine on U937 and CEM cell lines. All these drugs induced apoptosis and increased intracellular hydrogen peroxide but not superoxide anions. The addition of acetyl-l-carnitine (ALC) was able to prevent the pro-oxidant effect of the drugs tested. Supplementation with ALC, deficient in certain cohorts of HIV-infected individuals, especially on high active antiretroviral therapy regimen, has been associated with favourable effects. These data suggest that one of these effects could be a direct anti-oxidant action.

Original languageEnglish
Pages (from-to)6612-6616
Number of pages5
JournalFEBS Letters
Volume580
Issue number28-29
DOIs
Publication statusPublished - Dec 11 2006

Fingerprint

Acetylcarnitine
Oxidative stress
Carnitine
Oxidative Stress
Pharmaceutical Preparations
Stavudine
Didanosine
U937 Cells
Zidovudine
Oxidants
Superoxides
Hydrogen Peroxide
HIV Infections
Reactive Oxygen Species
Cells
HIV
Apoptosis
Cell Line
Therapeutics

Keywords

  • Acetyl-l-carnitine
  • Apoptosis
  • Flow cytometry
  • Mitochondrial membrane potential
  • NRTIs
  • ROS

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Ferraresi, R., Troiano, L., Roat, E., Nemes, E., Lugli, E., Nasi, M., ... Cossarizza, A. (2006). Protective effect of acetyl-l-carnitine against oxidative stress induced by antiretroviral drugs. FEBS Letters, 580(28-29), 6612-6616. https://doi.org/10.1016/j.febslet.2006.11.016

Protective effect of acetyl-l-carnitine against oxidative stress induced by antiretroviral drugs. / Ferraresi, Roberta; Troiano, Leonarda; Roat, Erika; Nemes, Elisa; Lugli, Enrico; Nasi, Milena; Pinti, Marcello; Calvani, Menotti; Iannuccelli, Maurizio; Cossarizza, Andrea.

In: FEBS Letters, Vol. 580, No. 28-29, 11.12.2006, p. 6612-6616.

Research output: Contribution to journalArticle

Ferraresi, R, Troiano, L, Roat, E, Nemes, E, Lugli, E, Nasi, M, Pinti, M, Calvani, M, Iannuccelli, M & Cossarizza, A 2006, 'Protective effect of acetyl-l-carnitine against oxidative stress induced by antiretroviral drugs', FEBS Letters, vol. 580, no. 28-29, pp. 6612-6616. https://doi.org/10.1016/j.febslet.2006.11.016
Ferraresi, Roberta ; Troiano, Leonarda ; Roat, Erika ; Nemes, Elisa ; Lugli, Enrico ; Nasi, Milena ; Pinti, Marcello ; Calvani, Menotti ; Iannuccelli, Maurizio ; Cossarizza, Andrea. / Protective effect of acetyl-l-carnitine against oxidative stress induced by antiretroviral drugs. In: FEBS Letters. 2006 ; Vol. 580, No. 28-29. pp. 6612-6616.
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