Abstract
A 10-min bilateral carotid occlusion (BCO) in a control group of Mongolian gerbils, induced a transient generalized epileptic activity both in the hippocampal and in the cortical regions, associated with motor manifestations. After recirculation, spiking activity persisted, reaching its maximum peak within 18-36 h and then slowly decreasing till its total disappearance on the 6th-7th day. On the 7th day, histological studies manifested a selective loss of CA1 hippocampal neurons. The treated gerbils (divided in 2 groups according to the dosage used) were administered clonazepam( CZP), a benzodiazepine receptor agonist, immediately after clamping and again every 24 h for the following three days at dosages of 0.05 and 0.1 mg/Kg i.p., respectively. The drug inhibited epileptic activity in a dose-dependent manner, while it prevented CA1 neuronal loss at both doses. These results point to a possible derangement of the GABAergic system which probably in turn triggers an exaggerated excitation.
| Original language | English |
|---|---|
| Pages (from-to) | 115-120 |
| Number of pages | 6 |
| Journal | Functional Neurology |
| Volume | 8 |
| Issue number | 2 |
| Publication status | Published - 1993 |
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Keywords
- CA1 neurons
- clonazepam
- epileptic activity
- gerbil
- ischemic damage
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Protective effect of clonazepam on ischemic brain damage induced by 10-minute bilateral carotid occlusion in Mongolian gerbils. / Marciani, M. G.; Santone, G.; Sancesario, G.; Massa, R.; Stanzione, P.; Bernardi, G.
In: Functional Neurology, Vol. 8, No. 2, 1993, p. 115-120.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Protective effect of clonazepam on ischemic brain damage induced by 10-minute bilateral carotid occlusion in Mongolian gerbils
AU - Marciani, M. G.
AU - Santone, G.
AU - Sancesario, G.
AU - Massa, R.
AU - Stanzione, P.
AU - Bernardi, G.
PY - 1993
Y1 - 1993
N2 - A 10-min bilateral carotid occlusion (BCO) in a control group of Mongolian gerbils, induced a transient generalized epileptic activity both in the hippocampal and in the cortical regions, associated with motor manifestations. After recirculation, spiking activity persisted, reaching its maximum peak within 18-36 h and then slowly decreasing till its total disappearance on the 6th-7th day. On the 7th day, histological studies manifested a selective loss of CA1 hippocampal neurons. The treated gerbils (divided in 2 groups according to the dosage used) were administered clonazepam( CZP), a benzodiazepine receptor agonist, immediately after clamping and again every 24 h for the following three days at dosages of 0.05 and 0.1 mg/Kg i.p., respectively. The drug inhibited epileptic activity in a dose-dependent manner, while it prevented CA1 neuronal loss at both doses. These results point to a possible derangement of the GABAergic system which probably in turn triggers an exaggerated excitation.
AB - A 10-min bilateral carotid occlusion (BCO) in a control group of Mongolian gerbils, induced a transient generalized epileptic activity both in the hippocampal and in the cortical regions, associated with motor manifestations. After recirculation, spiking activity persisted, reaching its maximum peak within 18-36 h and then slowly decreasing till its total disappearance on the 6th-7th day. On the 7th day, histological studies manifested a selective loss of CA1 hippocampal neurons. The treated gerbils (divided in 2 groups according to the dosage used) were administered clonazepam( CZP), a benzodiazepine receptor agonist, immediately after clamping and again every 24 h for the following three days at dosages of 0.05 and 0.1 mg/Kg i.p., respectively. The drug inhibited epileptic activity in a dose-dependent manner, while it prevented CA1 neuronal loss at both doses. These results point to a possible derangement of the GABAergic system which probably in turn triggers an exaggerated excitation.
KW - CA1 neurons
KW - clonazepam
KW - epileptic activity
KW - gerbil
KW - ischemic damage
UR - http://www.scopus.com/inward/record.url?scp=0027190024&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027190024&partnerID=8YFLogxK
M3 - Article
VL - 8
SP - 115
EP - 120
JO - Functional Neurology
JF - Functional Neurology
SN - 0393-5264
IS - 2
ER -