Abstract
A 10-min bilateral carotid occlusion (BCO) in a control group of Mongolian gerbils, induced a transient generalized epileptic activity both in the hippocampal and in the cortical regions, associated with motor manifestations. After recirculation, spiking activity persisted, reaching its maximum peak within 18-36 h and then slowly decreasing till its total disappearance on the 6th-7th day. On the 7th day, histological studies manifested a selective loss of CA1 hippocampal neurons. The treated gerbils (divided in 2 groups according to the dosage used) were administered clonazepam( CZP), a benzodiazepine receptor agonist, immediately after clamping and again every 24 h for the following three days at dosages of 0.05 and 0.1 mg/Kg i.p., respectively. The drug inhibited epileptic activity in a dose-dependent manner, while it prevented CA1 neuronal loss at both doses. These results point to a possible derangement of the GABAergic system which probably in turn triggers an exaggerated excitation.
Original language | English |
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Pages (from-to) | 115-120 |
Number of pages | 6 |
Journal | Functional Neurology |
Volume | 8 |
Issue number | 2 |
Publication status | Published - 1993 |
Keywords
- CA1 neurons
- clonazepam
- epileptic activity
- gerbil
- ischemic damage
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)