Protective effect of clonazepam on ischemic brain damage induced by 10-minute bilateral carotid occlusion in Mongolian gerbils

M. G. Marciani, G. Santone, G. Sancesario, R. Massa, P. Stanzione, G. Bernardi

Research output: Contribution to journalArticle

Abstract

A 10-min bilateral carotid occlusion (BCO) in a control group of Mongolian gerbils, induced a transient generalized epileptic activity both in the hippocampal and in the cortical regions, associated with motor manifestations. After recirculation, spiking activity persisted, reaching its maximum peak within 18-36 h and then slowly decreasing till its total disappearance on the 6th-7th day. On the 7th day, histological studies manifested a selective loss of CA1 hippocampal neurons. The treated gerbils (divided in 2 groups according to the dosage used) were administered clonazepam( CZP), a benzodiazepine receptor agonist, immediately after clamping and again every 24 h for the following three days at dosages of 0.05 and 0.1 mg/Kg i.p., respectively. The drug inhibited epileptic activity in a dose-dependent manner, while it prevented CA1 neuronal loss at both doses. These results point to a possible derangement of the GABAergic system which probably in turn triggers an exaggerated excitation.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalFunctional Neurology
Volume8
Issue number2
Publication statusPublished - 1993

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Keywords

  • CA1 neurons
  • clonazepam
  • epileptic activity
  • gerbil
  • ischemic damage

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Marciani, M. G., Santone, G., Sancesario, G., Massa, R., Stanzione, P., & Bernardi, G. (1993). Protective effect of clonazepam on ischemic brain damage induced by 10-minute bilateral carotid occlusion in Mongolian gerbils. Functional Neurology, 8(2), 115-120.