Protective effect of cyanidin (IdB 1027) against aspirin-induced fall in gastric transmucosal potential difference in normal subjects

N. Barzaghi, G. Gatti, F. Crema, E. Perucca

Research output: Contribution to journalArticle

Abstract

The effect of the natural flavonoid cyanidin (IdB 1027), 1200 mg daily for 8 days, on the fall in gastric transmucosal potential difference induced by a single dose of aspirin (1000 mg by nasogastric tube) was evaluated in 7 normal male volunteers. As compared to pretreatment values, IdB 1027 caused a significant reduction in both the percentage fall in transmucosal potential difference at the time of peak aspirin effect (from 37 ± 18% to 18 ± 5%, p <0.05) and the area under potential difference baseline (from 811 ± 624 mvolt. min to 338 ± 150 mvolt. min, p <0.05). These results provide evidence for a protecting effect of IdB 1027 against aspirin-induced gastric mucosal damage in man.

Original languageEnglish
Pages (from-to)249-252
Number of pages4
JournalItalian Journal of Gastroenterology
Volume23
Issue number5
Publication statusPublished - 1991

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Aspirin
Stomach
Flavonoids
Healthy Volunteers
cyanidin

ASJC Scopus subject areas

  • Gastroenterology

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Protective effect of cyanidin (IdB 1027) against aspirin-induced fall in gastric transmucosal potential difference in normal subjects. / Barzaghi, N.; Gatti, G.; Crema, F.; Perucca, E.

In: Italian Journal of Gastroenterology, Vol. 23, No. 5, 1991, p. 249-252.

Research output: Contribution to journalArticle

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