Abstract
The effect of the natural flavonoid cyanidin (IdB 1027), 1200 mg daily for 8 days, on the fall in gastric transmucosal potential difference induced by a single dose of aspirin (1000 mg by nasogastric tube) was evaluated in 7 normal male volunteers. As compared to pretreatment values, IdB 1027 caused a significant reduction in both the percentage fall in transmucosal potential difference at the time of peak aspirin effect (from 37 ± 18% to 18 ± 5%, p <0.05) and the area under potential difference baseline (from 811 ± 624 mvolt. min to 338 ± 150 mvolt. min, p <0.05). These results provide evidence for a protecting effect of IdB 1027 against aspirin-induced gastric mucosal damage in man.
| Original language | English |
|---|---|
| Pages (from-to) | 249-252 |
| Number of pages | 4 |
| Journal | Italian Journal of Gastroenterology |
| Volume | 23 |
| Issue number | 5 |
| Publication status | Published - 1991 |
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ASJC Scopus subject areas
- Gastroenterology
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Protective effect of cyanidin (IdB 1027) against aspirin-induced fall in gastric transmucosal potential difference in normal subjects. / Barzaghi, N.; Gatti, G.; Crema, F.; Perucca, E.
In: Italian Journal of Gastroenterology, Vol. 23, No. 5, 1991, p. 249-252.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Protective effect of cyanidin (IdB 1027) against aspirin-induced fall in gastric transmucosal potential difference in normal subjects
AU - Barzaghi, N.
AU - Gatti, G.
AU - Crema, F.
AU - Perucca, E.
PY - 1991
Y1 - 1991
N2 - The effect of the natural flavonoid cyanidin (IdB 1027), 1200 mg daily for 8 days, on the fall in gastric transmucosal potential difference induced by a single dose of aspirin (1000 mg by nasogastric tube) was evaluated in 7 normal male volunteers. As compared to pretreatment values, IdB 1027 caused a significant reduction in both the percentage fall in transmucosal potential difference at the time of peak aspirin effect (from 37 ± 18% to 18 ± 5%, p <0.05) and the area under potential difference baseline (from 811 ± 624 mvolt. min to 338 ± 150 mvolt. min, p <0.05). These results provide evidence for a protecting effect of IdB 1027 against aspirin-induced gastric mucosal damage in man.
AB - The effect of the natural flavonoid cyanidin (IdB 1027), 1200 mg daily for 8 days, on the fall in gastric transmucosal potential difference induced by a single dose of aspirin (1000 mg by nasogastric tube) was evaluated in 7 normal male volunteers. As compared to pretreatment values, IdB 1027 caused a significant reduction in both the percentage fall in transmucosal potential difference at the time of peak aspirin effect (from 37 ± 18% to 18 ± 5%, p <0.05) and the area under potential difference baseline (from 811 ± 624 mvolt. min to 338 ± 150 mvolt. min, p <0.05). These results provide evidence for a protecting effect of IdB 1027 against aspirin-induced gastric mucosal damage in man.
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M3 - Article
C2 - 1742514
AN - SCOPUS:0025828403
VL - 23
SP - 249
EP - 252
JO - Italian Journal of Gastroenterology
JF - Italian Journal of Gastroenterology
SN - 0392-0623
IS - 5
ER -