Protective effect of cyanidin (IdB 1027) against aspirin-induced fall in gastric transmucosal potential difference in normal subjects

The effect of the natural flavonoid cyanidin (IdB 1027), 1200 mg daily for 8 days, on the fall in gastric transmucosal potential difference induced by a single dose of aspirin (1000 mg by nasogastric tube) was evaluated in 7 normal male volunteers. As compared to pretreatment values, IdB 1027 caused a significant reduction in both the percentage fall in transmucosal potential difference at the time of peak aspirin effect (from 37 ± 18% to 18 ± 5%, p <0.05) and the area under potential difference baseline (from 811 ± 624 mvolt. min to 338 ± 150 mvolt. min, p <0.05). These results provide evidence for a protecting effect of IdB 1027 against aspirin-induced gastric mucosal damage in man.