Protective effect of N-acetylcysteine in a model of influenza infection in mice

D. Ungheri, C. Pinasi, G. Sanson, A. Bertani, G. Schioppacassi, R. Delgado, M. Sironi, P. Ghezzi

Research output: Contribution to journalArticlepeer-review


Reactive oxygen intermediates (ROI) and cytokines, particularly tumor necrosis factor (TNF) have been implicated in the pathogenesis of influenza. Using a murine model of influenza, we have studied the levels of TNF, interleukin 6 (IL-6) and of superoxide-generating xanthine oxidase (XO). Mice infected intranasally with influenza virus APR/8 had high levels of XO, TNF and IL-6 in the broncoalveolar lavage, as early as 3 d after infection. XO was elevated also in serum and lung tissue. Administration of the antioxidant N-acetylcysteine (NAC, 1 g/kg per day, orally) significantly decreased the mortality in infected mice, indicating a role for ROI in the lethality associated with influenza infection.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalInternational Journal of Immunopathology and Pharmacology
Issue number3
Publication statusPublished - 2000


  • Influenza
  • N-acetylcysteine
  • TNF

ASJC Scopus subject areas

  • Pharmacology


Dive into the research topics of 'Protective effect of N-acetylcysteine in a model of influenza infection in mice'. Together they form a unique fingerprint.

Cite this