Protective effect of N-acetylcysteine in a model of influenza infection in mice

D. Ungheri, C. Pinasi, G. Sanson, A. Bertani, G. Schioppacassi, R. Delgado, M. Sironi, P. Ghezzi

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Reactive oxygen intermediates (ROI) and cytokines, particularly tumor necrosis factor (TNF) have been implicated in the pathogenesis of influenza. Using a murine model of influenza, we have studied the levels of TNF, interleukin 6 (IL-6) and of superoxide-generating xanthine oxidase (XO). Mice infected intranasally with influenza virus APR/8 had high levels of XO, TNF and IL-6 in the broncoalveolar lavage, as early as 3 d after infection. XO was elevated also in serum and lung tissue. Administration of the antioxidant N-acetylcysteine (NAC, 1 g/kg per day, orally) significantly decreased the mortality in infected mice, indicating a role for ROI in the lethality associated with influenza infection.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalInternational Journal of Immunopathology and Pharmacology
Volume13
Issue number3
Publication statusPublished - 2000

Fingerprint

Xanthine Oxidase
Acetylcysteine
Human Influenza
Tumor Necrosis Factor-alpha
Interleukin-6
Infection
Oxygen
Therapeutic Irrigation
Orthomyxoviridae
Superoxides
Antioxidants
Cytokines
Lung
Mortality
Serum

Keywords

  • Influenza
  • N-acetylcysteine
  • TNF

ASJC Scopus subject areas

  • Pharmacology

Cite this

Ungheri, D., Pinasi, C., Sanson, G., Bertani, A., Schioppacassi, G., Delgado, R., ... Ghezzi, P. (2000). Protective effect of N-acetylcysteine in a model of influenza infection in mice. International Journal of Immunopathology and Pharmacology, 13(3), 123-128.

Protective effect of N-acetylcysteine in a model of influenza infection in mice. / Ungheri, D.; Pinasi, C.; Sanson, G.; Bertani, A.; Schioppacassi, G.; Delgado, R.; Sironi, M.; Ghezzi, P.

In: International Journal of Immunopathology and Pharmacology, Vol. 13, No. 3, 2000, p. 123-128.

Research output: Contribution to journalArticle

Ungheri, D, Pinasi, C, Sanson, G, Bertani, A, Schioppacassi, G, Delgado, R, Sironi, M & Ghezzi, P 2000, 'Protective effect of N-acetylcysteine in a model of influenza infection in mice', International Journal of Immunopathology and Pharmacology, vol. 13, no. 3, pp. 123-128.
Ungheri D, Pinasi C, Sanson G, Bertani A, Schioppacassi G, Delgado R et al. Protective effect of N-acetylcysteine in a model of influenza infection in mice. International Journal of Immunopathology and Pharmacology. 2000;13(3):123-128.
Ungheri, D. ; Pinasi, C. ; Sanson, G. ; Bertani, A. ; Schioppacassi, G. ; Delgado, R. ; Sironi, M. ; Ghezzi, P. / Protective effect of N-acetylcysteine in a model of influenza infection in mice. In: International Journal of Immunopathology and Pharmacology. 2000 ; Vol. 13, No. 3. pp. 123-128.
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