Protective effect of N-acetylcysteine in a model of influenza infection in mice

D. Ungheri, C. Pinasi, G. Sanson, A. Bertani, G. Schioppacassi, R. Delgado, M. Sironi, P. Ghezzi

Research output: Contribution to journalArticle

Abstract

Reactive oxygen intermediates (ROI) and cytokines, particularly tumor necrosis factor (TNF) have been implicated in the pathogenesis of influenza. Using a murine model of influenza, we have studied the levels of TNF, interleukin 6 (IL-6) and of superoxide-generating xanthine oxidase (XO). Mice infected intranasally with influenza virus APR/8 had high levels of XO, TNF and IL-6 in the broncoalveolar lavage, as early as 3 d after infection. XO was elevated also in serum and lung tissue. Administration of the antioxidant N-acetylcysteine (NAC, 1 g/kg per day, orally) significantly decreased the mortality in infected mice, indicating a role for ROI in the lethality associated with influenza infection.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalInternational Journal of Immunopathology and Pharmacology
Volume13
Issue number3
Publication statusPublished - 2000

Keywords

  • Influenza
  • N-acetylcysteine
  • TNF

ASJC Scopus subject areas

  • Pharmacology

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  • Cite this

    Ungheri, D., Pinasi, C., Sanson, G., Bertani, A., Schioppacassi, G., Delgado, R., Sironi, M., & Ghezzi, P. (2000). Protective effect of N-acetylcysteine in a model of influenza infection in mice. International Journal of Immunopathology and Pharmacology, 13(3), 123-128.