Abstract
Reactive oxygen intermediates (ROI) and cytokines, particularly tumor necrosis factor (TNF) have been implicated in the pathogenesis of influenza. Using a murine model of influenza, we have studied the levels of TNF, interleukin 6 (IL-6) and of superoxide-generating xanthine oxidase (XO). Mice infected intranasally with influenza virus APR/8 had high levels of XO, TNF and IL-6 in the broncoalveolar lavage, as early as 3 d after infection. XO was elevated also in serum and lung tissue. Administration of the antioxidant N-acetylcysteine (NAC, 1 g/kg per day, orally) significantly decreased the mortality in infected mice, indicating a role for ROI in the lethality associated with influenza infection.
| Original language | English |
|---|---|
| Pages (from-to) | 123-128 |
| Number of pages | 6 |
| Journal | International Journal of Immunopathology and Pharmacology |
| Volume | 13 |
| Issue number | 3 |
| Publication status | Published - 2000 |
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Keywords
- Influenza
- N-acetylcysteine
- TNF
ASJC Scopus subject areas
- Pharmacology
Cite this
Protective effect of N-acetylcysteine in a model of influenza infection in mice. / Ungheri, D.; Pinasi, C.; Sanson, G.; Bertani, A.; Schioppacassi, G.; Delgado, R.; Sironi, M.; Ghezzi, P.
In: International Journal of Immunopathology and Pharmacology, Vol. 13, No. 3, 2000, p. 123-128.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Protective effect of N-acetylcysteine in a model of influenza infection in mice
AU - Ungheri, D.
AU - Pinasi, C.
AU - Sanson, G.
AU - Bertani, A.
AU - Schioppacassi, G.
AU - Delgado, R.
AU - Sironi, M.
AU - Ghezzi, P.
PY - 2000
Y1 - 2000
N2 - Reactive oxygen intermediates (ROI) and cytokines, particularly tumor necrosis factor (TNF) have been implicated in the pathogenesis of influenza. Using a murine model of influenza, we have studied the levels of TNF, interleukin 6 (IL-6) and of superoxide-generating xanthine oxidase (XO). Mice infected intranasally with influenza virus APR/8 had high levels of XO, TNF and IL-6 in the broncoalveolar lavage, as early as 3 d after infection. XO was elevated also in serum and lung tissue. Administration of the antioxidant N-acetylcysteine (NAC, 1 g/kg per day, orally) significantly decreased the mortality in infected mice, indicating a role for ROI in the lethality associated with influenza infection.
AB - Reactive oxygen intermediates (ROI) and cytokines, particularly tumor necrosis factor (TNF) have been implicated in the pathogenesis of influenza. Using a murine model of influenza, we have studied the levels of TNF, interleukin 6 (IL-6) and of superoxide-generating xanthine oxidase (XO). Mice infected intranasally with influenza virus APR/8 had high levels of XO, TNF and IL-6 in the broncoalveolar lavage, as early as 3 d after infection. XO was elevated also in serum and lung tissue. Administration of the antioxidant N-acetylcysteine (NAC, 1 g/kg per day, orally) significantly decreased the mortality in infected mice, indicating a role for ROI in the lethality associated with influenza infection.
KW - Influenza
KW - N-acetylcysteine
KW - TNF
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UR - http://www.scopus.com/inward/citedby.url?scp=0034533766&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0034533766
VL - 13
SP - 123
EP - 128
JO - International Journal of Immunopathology and Pharmacology
JF - International Journal of Immunopathology and Pharmacology
SN - 0394-6320
IS - 3
ER -