Protective effect of pre-infarction angina on microvascular obstruction after primary percutaneous coronary intervention is blunted in humans by cardiovascular risk factors

Giampaolo Niccoli, Giancarla Scalone, Nicola Cosentino, Alessandro Fabretti, Alessandro Mandurino Mirizzi, Mario Gramegna, Mario Panebianco, Marco Roberto, Filippo Crea

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Pre-infarction angina (PIA) has been shown to reduce the microvascular obstruction (MVO) rate in patients with ST-segment elevation myocardial infarction (STEMI). We sought to evaluate the potential modulator role of cardiovascular risk factors (CRFs) on this protective effect. Methods and Results: Two hundred patients with STEMI were enrolled. PIA was defined as typical chest pain within the 48 h preceding STEMI onset. Angiographic MVO was defined as TIMI flow grade

Original languageEnglish
Pages (from-to)1935-1941
Number of pages7
JournalCirculation Journal
Volume78
Issue number8
DOIs
Publication statusPublished - 2014

Keywords

  • Acute myocardial infarction
  • Microcirculation
  • Percutaneous coronary intervention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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