Abstract
Reperfusion of isolated rabbit heart after 60 min of ischaemia resulted in poor recovery of mechanical function, release of reduced (GSH) and oxidized glutathione (GSSG), reduction of tissue GSH/GSSG ratio and shift of cellular thiol redox state toward oxidation, suggesting the occurrence of oxidative stress. Pretreatment of the isolated heart with propionyl-L-carnitine (10-7M) improved the functional recovery of the myocardium, reduced GSH and GSSG release and attenuated the accumulation of tissue GSSG. This effect was specific for propionyl-L-carnitine as L-carnitine and propionyl acid did not modify myocardial damage.
Original language | English |
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Pages (from-to) | 161-168 |
Number of pages | 8 |
Journal | Molecular and Cellular Biochemistry |
Volume | 88 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - Mar 1989 |
Keywords
- myocardial-protection
- oxidative damage
- post-ischaemic reperfusion
- propionyl-L-carnitine
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Clinical Biochemistry
- Cell Biology