Protective effect of propionyl-L-carnitine against ischaemia and reperfusion-damage

Roberto Ferrari; Claudio Ceconi; Salvatore Curello; Evasio Pasini; Odoardo Visioli

doi:10.1007/BF00223438

Protective effect of propionyl-L-carnitine against ischaemia and reperfusion-damage

Roberto Ferrari, Claudio Ceconi, Salvatore Curello, Evasio Pasini, Odoardo Visioli

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

Reperfusion of isolated rabbit heart after 60 min of ischaemia resulted in poor recovery of mechanical function, release of reduced (GSH) and oxidized glutathione (GSSG), reduction of tissue GSH/GSSG ratio and shift of cellular thiol redox state toward oxidation, suggesting the occurrence of oxidative stress. Pretreatment of the isolated heart with propionyl-L-carnitine (10^-7M) improved the functional recovery of the myocardium, reduced GSH and GSSG release and attenuated the accumulation of tissue GSSG. This effect was specific for propionyl-L-carnitine as L-carnitine and propionyl acid did not modify myocardial damage.

Original language	English
Pages (from-to)	161-168
Number of pages	8
Journal	Molecular and Cellular Biochemistry
Volume	88
Issue number	1-2
DOIs	https://doi.org/10.1007/BF00223438
Publication status	Published - Mar 1989

Keywords

myocardial-protection
oxidative damage
post-ischaemic reperfusion
propionyl-L-carnitine

ASJC Scopus subject areas

Molecular Biology
Genetics
Clinical Biochemistry
Cell Biology

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10.1007/BF00223438

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abstract = "Reperfusion of isolated rabbit heart after 60 min of ischaemia resulted in poor recovery of mechanical function, release of reduced (GSH) and oxidized glutathione (GSSG), reduction of tissue GSH/GSSG ratio and shift of cellular thiol redox state toward oxidation, suggesting the occurrence of oxidative stress. Pretreatment of the isolated heart with propionyl-L-carnitine (10-7M) improved the functional recovery of the myocardium, reduced GSH and GSSG release and attenuated the accumulation of tissue GSSG. This effect was specific for propionyl-L-carnitine as L-carnitine and propionyl acid did not modify myocardial damage.",

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AU - Ferrari, Roberto

AU - Ceconi, Claudio

AU - Curello, Salvatore

AU - Pasini, Evasio

AU - Visioli, Odoardo

PY - 1989/3

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AB - Reperfusion of isolated rabbit heart after 60 min of ischaemia resulted in poor recovery of mechanical function, release of reduced (GSH) and oxidized glutathione (GSSG), reduction of tissue GSH/GSSG ratio and shift of cellular thiol redox state toward oxidation, suggesting the occurrence of oxidative stress. Pretreatment of the isolated heart with propionyl-L-carnitine (10-7M) improved the functional recovery of the myocardium, reduced GSH and GSSG release and attenuated the accumulation of tissue GSSG. This effect was specific for propionyl-L-carnitine as L-carnitine and propionyl acid did not modify myocardial damage.

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Protective effect of propionyl-L-carnitine against ischaemia and reperfusion-damage

Abstract

Keywords

ASJC Scopus subject areas

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