Protective effect of propionyl-L-carnitine against ischaemia and reperfusion-damage

Roberto Ferrari, Claudio Ceconi, Salvatore Curello, Evasio Pasini, Odoardo Visioli

Research output: Contribution to journalArticlepeer-review


Reperfusion of isolated rabbit heart after 60 min of ischaemia resulted in poor recovery of mechanical function, release of reduced (GSH) and oxidized glutathione (GSSG), reduction of tissue GSH/GSSG ratio and shift of cellular thiol redox state toward oxidation, suggesting the occurrence of oxidative stress. Pretreatment of the isolated heart with propionyl-L-carnitine (10-7M) improved the functional recovery of the myocardium, reduced GSH and GSSG release and attenuated the accumulation of tissue GSSG. This effect was specific for propionyl-L-carnitine as L-carnitine and propionyl acid did not modify myocardial damage.

Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalMolecular and Cellular Biochemistry
Issue number1-2
Publication statusPublished - Mar 1989


  • myocardial-protection
  • oxidative damage
  • post-ischaemic reperfusion
  • propionyl-L-carnitine

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology


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