Protective effect of propionyl-L-carnitine against ischaemia and reperfusion-damage

Roberto Ferrari, Claudio Ceconi, Salvatore Curello, Evasio Pasini, Odoardo Visioli

Research output: Contribution to journalArticle

Abstract

Reperfusion of isolated rabbit heart after 60 min of ischaemia resulted in poor recovery of mechanical function, release of reduced (GSH) and oxidized glutathione (GSSG), reduction of tissue GSH/GSSG ratio and shift of cellular thiol redox state toward oxidation, suggesting the occurrence of oxidative stress. Pretreatment of the isolated heart with propionyl-L-carnitine (10-7M) improved the functional recovery of the myocardium, reduced GSH and GSSG release and attenuated the accumulation of tissue GSSG. This effect was specific for propionyl-L-carnitine as L-carnitine and propionyl acid did not modify myocardial damage.

Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalMolecular and Cellular Biochemistry
Volume88
Issue number1-2
DOIs
Publication statusPublished - Mar 1989

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Keywords

  • myocardial-protection
  • oxidative damage
  • post-ischaemic reperfusion
  • propionyl-L-carnitine

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

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