Abstract
Reperfusion of isolated rabbit heart after 60 min of ischaemia resulted in poor recovery of mechanical function, release of reduced (GSH) and oxidized glutathione (GSSG), reduction of tissue GSH/GSSG ratio and shift of cellular thiol redox state toward oxidation, suggesting the occurrence of oxidative stress. Pretreatment of the isolated heart with propionyl-L-carnitine (10-7M) improved the functional recovery of the myocardium, reduced GSH and GSSG release and attenuated the accumulation of tissue GSSG. This effect was specific for propionyl-L-carnitine as L-carnitine and propionyl acid did not modify myocardial damage.
| Original language | English |
|---|---|
| Pages (from-to) | 161-168 |
| Number of pages | 8 |
| Journal | Molecular and Cellular Biochemistry |
| Volume | 88 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Mar 1989 |
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Keywords
- myocardial-protection
- oxidative damage
- post-ischaemic reperfusion
- propionyl-L-carnitine
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Clinical Biochemistry
- Cell Biology
Cite this
Protective effect of propionyl-L-carnitine against ischaemia and reperfusion-damage. / Ferrari, Roberto; Ceconi, Claudio; Curello, Salvatore; Pasini, Evasio; Visioli, Odoardo.
In: Molecular and Cellular Biochemistry, Vol. 88, No. 1-2, 03.1989, p. 161-168.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Protective effect of propionyl-L-carnitine against ischaemia and reperfusion-damage
AU - Ferrari, Roberto
AU - Ceconi, Claudio
AU - Curello, Salvatore
AU - Pasini, Evasio
AU - Visioli, Odoardo
PY - 1989/3
Y1 - 1989/3
N2 - Reperfusion of isolated rabbit heart after 60 min of ischaemia resulted in poor recovery of mechanical function, release of reduced (GSH) and oxidized glutathione (GSSG), reduction of tissue GSH/GSSG ratio and shift of cellular thiol redox state toward oxidation, suggesting the occurrence of oxidative stress. Pretreatment of the isolated heart with propionyl-L-carnitine (10-7M) improved the functional recovery of the myocardium, reduced GSH and GSSG release and attenuated the accumulation of tissue GSSG. This effect was specific for propionyl-L-carnitine as L-carnitine and propionyl acid did not modify myocardial damage.
AB - Reperfusion of isolated rabbit heart after 60 min of ischaemia resulted in poor recovery of mechanical function, release of reduced (GSH) and oxidized glutathione (GSSG), reduction of tissue GSH/GSSG ratio and shift of cellular thiol redox state toward oxidation, suggesting the occurrence of oxidative stress. Pretreatment of the isolated heart with propionyl-L-carnitine (10-7M) improved the functional recovery of the myocardium, reduced GSH and GSSG release and attenuated the accumulation of tissue GSSG. This effect was specific for propionyl-L-carnitine as L-carnitine and propionyl acid did not modify myocardial damage.
KW - myocardial-protection
KW - oxidative damage
KW - post-ischaemic reperfusion
KW - propionyl-L-carnitine
UR - http://www.scopus.com/inward/record.url?scp=0024403884&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024403884&partnerID=8YFLogxK
U2 - 10.1007/BF00223438
DO - 10.1007/BF00223438
M3 - Article
VL - 88
SP - 161
EP - 168
JO - Molecular and Cellular Biochemistry
JF - Molecular and Cellular Biochemistry
SN - 0300-8177
IS - 1-2
ER -