Protective effect of propionyl-L-carnitine against ischaemia and reperfusion-damage

Roberto Ferrari, Claudio Ceconi, Salvatore Curello, Evasio Pasini, Odoardo Visioli

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Reperfusion of isolated rabbit heart after 60 min of ischaemia resulted in poor recovery of mechanical function, release of reduced (GSH) and oxidized glutathione (GSSG), reduction of tissue GSH/GSSG ratio and shift of cellular thiol redox state toward oxidation, suggesting the occurrence of oxidative stress. Pretreatment of the isolated heart with propionyl-L-carnitine (10-7M) improved the functional recovery of the myocardium, reduced GSH and GSSG release and attenuated the accumulation of tissue GSSG. This effect was specific for propionyl-L-carnitine as L-carnitine and propionyl acid did not modify myocardial damage.

Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalMolecular and Cellular Biochemistry
Volume88
Issue number1-2
DOIs
Publication statusPublished - Mar 1989

Fingerprint

propionylcarnitine
Glutathione Disulfide
Carnitine
Reperfusion Injury
Ischemia
Tissue
Recovery
Oxidative stress
Recovery of Function
Sulfhydryl Compounds
Reperfusion
Oxidation-Reduction
Glutathione
Myocardium
Oxidative Stress
Rabbits
Oxidation

Keywords

  • myocardial-protection
  • oxidative damage
  • post-ischaemic reperfusion
  • propionyl-L-carnitine

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

Cite this

Protective effect of propionyl-L-carnitine against ischaemia and reperfusion-damage. / Ferrari, Roberto; Ceconi, Claudio; Curello, Salvatore; Pasini, Evasio; Visioli, Odoardo.

In: Molecular and Cellular Biochemistry, Vol. 88, No. 1-2, 03.1989, p. 161-168.

Research output: Contribution to journalArticle

Ferrari, Roberto ; Ceconi, Claudio ; Curello, Salvatore ; Pasini, Evasio ; Visioli, Odoardo. / Protective effect of propionyl-L-carnitine against ischaemia and reperfusion-damage. In: Molecular and Cellular Biochemistry. 1989 ; Vol. 88, No. 1-2. pp. 161-168.
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