Protective effect of some exogenous glycolipids on human cultured keratinocytes against lipid peroxidation

I. Varani, A. Terzaghi, L. Donati, M. Marazzi, M. Masserini, G. Tettamanti

Research output: Contribution to journalArticle

Abstract

Cultured human keratinocytes were incubated in the presence of glycolipids (GM1, asialoGM1, glucosylceramide and galactosylceramide) added to the medium at a concentration of 10-5M. All of them became associated with the cells, but in different amounts depending on the type of glycolipid and on the time in culture. GM1- and asialoGM1-treated keratinocytes developed a resistance to peroxidative stress induced by FeSO4/H2O2 treatment. These results suggest that these exogenously added glycolipids could play a role as eutrophic, repairing and protective agents for the epidermis.

Original languageEnglish
Pages (from-to)481-483
Number of pages3
JournalArchives of Dermatological Research
Volume286
Issue number8
DOIs
Publication statusPublished - Oct 1994

Keywords

  • Glycolipids
  • Keratinocytes
  • Peroxidation

ASJC Scopus subject areas

  • Dermatology

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