Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death

Valeria Bruno, Agata Copani, Giuseppe Battaglia, Rocco Raffaele, Huruiko Shinozaki, Ferdinando Nicoletti

Research output: Contribution to journalArticle

Abstract

(2S,1′R,2′R,3′R)-2-(2,3-Dicarboxycyclopropyl)glycine (DCG-IV), a potent agonist of subtypes 2 and 3 of metabotropic glutamate receptors (mGluR2 or 3), protected cultured cortical neurons against excitotoxicity induced either by a brief exposure to N-methyl-D-aspartate (NMDA) or a prolonged exposure to kainate. As a neuroprotective agent, DCG-IV was much more potent than the mixed agonists 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) or (2S,1′S,2′S)-2 (carboxycyclopropyl)glycine (L-CCG-I), suggesting a neuroprotective role for mGluR2 or 3 against excitotoxic neuronal death,.

Original languageEnglish
Pages (from-to)109-112
Number of pages4
JournalEuropean Journal of Pharmacology
Volume256
Issue number1
DOIs
Publication statusPublished - Apr 11 1994

Keywords

  • Cortical neuron
  • DCG-IV ((2S,1′R,2′R,3′R)-2-(2,3-dicarboxycyclopropyl)glycine)
  • Excitotoxicity
  • Metabotropic glutamate receptor

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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