Protective effect on cisplatin hematotoxicity by procaine hydrochloride

Mauro Esposito, Roberto Lerza, Manlio Mencoboni, Maria Vannozzi, Guia Flego, Giuseppe Bogliolo, Franco Merlo, Ivo Pannacciulli

Research output: Contribution to journalArticlepeer-review

Abstract

The ability of procaine hydrochloride (P.HCl) to modulate the effects of cisplatin (DDP) on pluripotent (CFU-S) and committed (CFU-GM) murine hemopoietic stem cells was investigated. DBA/2NCrlBRF1 mice received DDP alone (10 and 16 mg/kg body wt. single i.p. injection) or in combination with P.HCl (40 mg/kg body wt. single i.p. injection). Hemopoietic progenitor cell (HPC) time survival curves were determined up to 14 days following treatment. The simultaneous administration of the lower DDP dose together with P.HCl greatly reduced the hemotoxicity of the antitumoral drug, while this protection was not significant with the higher DDP dose. These results support a role for P.HCl in protecting against DDP hematological toxicity.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalCancer Letters
Volume64
Issue number1
DOIs
Publication statusPublished - May 30 1992

Keywords

  • cisplatin
  • hematoxicity
  • procaine

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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