Protective effects of glycyrrhizin in a gut hypoxia (ischemia)- reoxygenation (reperfusion) model

Rosanna Di Paola, Marta Menegazzi, Emanuela Mazzon, Tiziana Genovese, Concetta Crisafulli, Martina Dal Bosco, Zhenzhen Zou, Hisanori Suzuki, Salvatore Cuzzocrea

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: This study investigated the effects of glycyrrhizin, a potent antioxidant, on tissue injury caused by ischemia/reperfusion (I/R) of the gut. Methods: I/R injury of the intestine was caused by clamping both the superior mesenteric artery and the celiac trunk for 45 min followed by release of the clamp allowing reperfusion for 1 or 6 h. Results: Administration of glycyrrhizin, significantly reduced the (a) fall of mean arterial blood pressure, (b) mortality rate, (c) myeloperoxidase (MPO) activity, (d) production of pro-inflammatory cytokines [tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β)], (e) histological evidence of gut injury, (f) immunoreactivity of nitrotyrosine, (g) poly ADP-ribose (PAR) formation, (h) the expression of ICAM-1 and P-selectin, (i) activation of nuclear factor-κB (NF-κB) and (j) signal transducer and activator transcription-3 (STAT-3) induced by splanchnic artery occlusion-reperfusion shock. Conclusions: This study demonstrates that glycyrrhizin exerts multiple protective effects in splanchnic artery occlusion-reperfusion shock.

Original languageEnglish
Pages (from-to)687-697
Number of pages11
JournalIntensive Care Medicine
Volume35
Issue number4
DOIs
Publication statusPublished - Apr 2009

Keywords

  • Cytokines
  • Glycyrrhizin
  • Ischemia-reperfusion injury
  • Oxidative stress
  • Polymorphonuclear leukocytes
  • Reactive oxygen species

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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