Protective effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in paw oedema induced by carrageenan in the rat

Salvatore Cuzzocrea, Giuseppina Costantino, Emanuela Mazzon, Basilia Zingarelli, Angela De Sarro, Achille P. Caputi

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study we investigated the therapeutic efficacy of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic which possesses peroxynitrite scavenging effects, in rats subjected to carrageenan-induced paw oedema. Local administration of MnTBAP (5, 25, and 50 μg/paw) significantly and dose dependently reduced carrageenan-induced paw oedema at all time points. MnTBAP also caused a significant dose-dependent reduction in paw myeloperoxidase activity and lipid peroxidation, as well as preventing histological injury. Immunohistochemical analysis for nitrotyrosine revealed a positive staining in paw from carrageenan-treated rats. No positive nitrotyrosine staining was found in the paws of the carrageenan-treated rats that received MnTBAP. Our study demonstrates that MnTBAP exerts protective effects in carrageenan-induced paw oedema. Part of these anti-inflammatory effects may be related to: 1) reduction of superoxide formation due to the superoxide dismutase-like activity of the compound; and 2) scavenging of peroxynitrite. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalBiochemical Pharmacology
Volume58
Issue number1
DOIs
Publication statusPublished - Jul 1 1999

Keywords

  • Carrageenan
  • Inflammation
  • Nitric oxide
  • Paw oedema
  • Peroxynitrite
  • Superoxide dismutase

ASJC Scopus subject areas

  • Pharmacology

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