TY - JOUR
T1 - Protective effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in paw oedema induced by carrageenan in the rat
AU - Cuzzocrea, Salvatore
AU - Costantino, Giuseppina
AU - Mazzon, Emanuela
AU - Zingarelli, Basilia
AU - De Sarro, Angela
AU - Caputi, Achille P.
PY - 1999/7/1
Y1 - 1999/7/1
N2 - In the present study we investigated the therapeutic efficacy of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic which possesses peroxynitrite scavenging effects, in rats subjected to carrageenan-induced paw oedema. Local administration of MnTBAP (5, 25, and 50 μg/paw) significantly and dose dependently reduced carrageenan-induced paw oedema at all time points. MnTBAP also caused a significant dose-dependent reduction in paw myeloperoxidase activity and lipid peroxidation, as well as preventing histological injury. Immunohistochemical analysis for nitrotyrosine revealed a positive staining in paw from carrageenan-treated rats. No positive nitrotyrosine staining was found in the paws of the carrageenan-treated rats that received MnTBAP. Our study demonstrates that MnTBAP exerts protective effects in carrageenan-induced paw oedema. Part of these anti-inflammatory effects may be related to: 1) reduction of superoxide formation due to the superoxide dismutase-like activity of the compound; and 2) scavenging of peroxynitrite. Copyright (C) 1999 Elsevier Science Inc.
AB - In the present study we investigated the therapeutic efficacy of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic which possesses peroxynitrite scavenging effects, in rats subjected to carrageenan-induced paw oedema. Local administration of MnTBAP (5, 25, and 50 μg/paw) significantly and dose dependently reduced carrageenan-induced paw oedema at all time points. MnTBAP also caused a significant dose-dependent reduction in paw myeloperoxidase activity and lipid peroxidation, as well as preventing histological injury. Immunohistochemical analysis for nitrotyrosine revealed a positive staining in paw from carrageenan-treated rats. No positive nitrotyrosine staining was found in the paws of the carrageenan-treated rats that received MnTBAP. Our study demonstrates that MnTBAP exerts protective effects in carrageenan-induced paw oedema. Part of these anti-inflammatory effects may be related to: 1) reduction of superoxide formation due to the superoxide dismutase-like activity of the compound; and 2) scavenging of peroxynitrite. Copyright (C) 1999 Elsevier Science Inc.
KW - Carrageenan
KW - Inflammation
KW - Nitric oxide
KW - Paw oedema
KW - Peroxynitrite
KW - Superoxide dismutase
UR - http://www.scopus.com/inward/record.url?scp=0033168991&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033168991&partnerID=8YFLogxK
U2 - 10.1016/S0006-2952(99)00067-2
DO - 10.1016/S0006-2952(99)00067-2
M3 - Article
C2 - 10403531
AN - SCOPUS:0033168991
VL - 58
SP - 171
EP - 176
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
SN - 0006-2952
IS - 1
ER -