Protective effects of proton pump inhibitors against indomethacin-induced lesions in the rat small intestine

Cristina Pozzoli, Alessandro Menozzi, Daniela Grandi, Elvira Solenghi, Maria C. Ossiprandi, Chiara Zullian, Simone Bertini, Giulia M. Cavestro, Gabriella Coruzzi

Research output: Contribution to journalArticle

Abstract

Proton pump inhibitors (PPIs) have been shown to be effective in preventing gastric and duodenal ulcers in high-risk patients taking nonsteroidal anti-inflammatory drugs (NSAIDs); by contrast, scarce information is available concerning the effects of PPIs on intestinal damage induced by NSAIDs in humans or in experimental animals. We examined the effects of lansoprazole and omeprazole on the intestinal injury induced by indomethacin in the conscious rat. PPIs were administered by the intragastric route at 30, 60 and 90 μmol/kg, 12 h and 30 min before and 6 h after indomethacin treatment. The effects of omeprazole and lansoprazole were evaluated on: (1) macroscopic and histologic damage; (2) mucosal polymorphonuclear cell infiltration; (3) oxidative tissue damage and (4) bacterial translocation from lumen into the intestinal mucosa. Lansoprazole and omeprazole (at 90 μmol/kg) significantly decreased (P

Original languageEnglish
Pages (from-to)283-291
Number of pages9
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume374
Issue number4
DOIs
Publication statusPublished - Jan 2007

Keywords

  • Indomethacin
  • Proton pump inhibitors
  • Rat
  • Small intestine

ASJC Scopus subject areas

  • Pharmacology

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