Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) Silencing

Jihyun Chung, Vrajesh Karkhanis, Sookil Tae, Fengting Yan, Porsha Smith, Leona W. Ayers, Claudio Agostinelli, Stefano Pileri, Gerald V. Denis, Robert A. Baiocchi, Saïd Sif

Research output: Contribution to journalArticle

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Abstract

Background: PRMT5, PRC2, and cyclin D1 are overexpressed in non-Hodgkin lymphoma (NHL). Results: PRMT5 expression inversely correlates with levels of hypophospho-RB1 and RBL2. Conclusion: PRMT5 inhibition reactivates RB1 and RBL2 and silences PRC2 and cyclin D1. Significance: PRMT5 inhibition results in NHL growth arrest and cell death.

Original languageEnglish
Pages (from-to)35534-35547
Number of pages14
JournalJournal of Biological Chemistry
Volume288
Issue number49
DOIs
Publication statusPublished - Dec 6 2013

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Protein-Arginine N-Methyltransferases
Retinoblastoma
Cell death
Tumors
Lymphoma
Cell Death
Cyclin D1
Non-Hodgkin's Lymphoma
Neoplasms
Growth

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) Silencing. / Chung, Jihyun; Karkhanis, Vrajesh; Tae, Sookil; Yan, Fengting; Smith, Porsha; Ayers, Leona W.; Agostinelli, Claudio; Pileri, Stefano; Denis, Gerald V.; Baiocchi, Robert A.; Sif, Saïd.

In: Journal of Biological Chemistry, Vol. 288, No. 49, 06.12.2013, p. 35534-35547.

Research output: Contribution to journalArticle

Chung, Jihyun ; Karkhanis, Vrajesh ; Tae, Sookil ; Yan, Fengting ; Smith, Porsha ; Ayers, Leona W. ; Agostinelli, Claudio ; Pileri, Stefano ; Denis, Gerald V. ; Baiocchi, Robert A. ; Sif, Saïd. / Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) Silencing. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 49. pp. 35534-35547.
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AU - Tae, Sookil

AU - Yan, Fengting

AU - Smith, Porsha

AU - Ayers, Leona W.

AU - Agostinelli, Claudio

AU - Pileri, Stefano

AU - Denis, Gerald V.

AU - Baiocchi, Robert A.

AU - Sif, Saïd

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