Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) Silencing

Jihyun Chung, Vrajesh Karkhanis, Sookil Tae, Fengting Yan, Porsha Smith, Leona W. Ayers, Claudio Agostinelli, Stefano Pileri, Gerald V. Denis, Robert A. Baiocchi, Saïd Sif

Research output: Contribution to journalArticle

Abstract

Background: PRMT5, PRC2, and cyclin D1 are overexpressed in non-Hodgkin lymphoma (NHL). Results: PRMT5 expression inversely correlates with levels of hypophospho-RB1 and RBL2. Conclusion: PRMT5 inhibition reactivates RB1 and RBL2 and silences PRC2 and cyclin D1. Significance: PRMT5 inhibition results in NHL growth arrest and cell death.

Original languageEnglish
Pages (from-to)35534-35547
Number of pages14
JournalJournal of Biological Chemistry
Volume288
Issue number49
DOIs
Publication statusPublished - Dec 6 2013

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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