Protein carbonyl group content in patients affected by familiar chronic nail candidiasis

S. Gangemi, A. Saija, A. Tomaino, F. Cimino, R. A. Merendino, P. L. Minciullo, S. Briuglia, M. V. Merlino, B. Dallapiccola, B. Ferlazzo, D. C. Salpietro

Research output: Contribution to journalArticle

Abstract

FAMILIAR chronic nail candidiasis (FCNC) is a rare disorder characterized by early-onset infections caused by different species of Candida, restricted to the nail of the hands and feet, and associated with a low serum concentration of intercellular adhesion molecule 1. Host defense mechanisms against candidiasis require the cooperation of many immune cells through several candidacidal mechanisms, including oxygen-dependent killing mechanisms, mediated by a superoxide anion radical myeloperoxidase-H2O 2-halide system, and reactive nitrogen intermediates. We analyzed protein carbonyl groups (considered a useful marker of oxidative stress) in the serum of patients belonging to a five-generation Italian family with an isolated form of FCNC. Serum protein carbonyl groups in FCNC patients were significantly lower than those measured in healthy donors. Also, if this hypothesis is merely speculative, we could suggest that the decreased circulating level of protein carbonyl groups in these patients is not a marker of a lower oxidative stress condition, but might be linked to a lower protease activity.

Original languageEnglish
Pages (from-to)247-249
Number of pages3
JournalMediators of Inflammation
Volume12
Issue number4
DOIs
Publication statusPublished - Aug 2003

Keywords

  • Chronic mucocutaneous candidiasis
  • Familiar chronic nail candidiasis
  • Oxidative stress
  • Protein carbonyl groups

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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    Gangemi, S., Saija, A., Tomaino, A., Cimino, F., Merendino, R. A., Minciullo, P. L., Briuglia, S., Merlino, M. V., Dallapiccola, B., Ferlazzo, B., & Salpietro, D. C. (2003). Protein carbonyl group content in patients affected by familiar chronic nail candidiasis. Mediators of Inflammation, 12(4), 247-249. https://doi.org/10.1080/09629350310001599693