Il contributo della diagnostica proteica nella gestione delle gammopatie monoclonali

Translated title of the contribution: Protein diagnostics in the management of monoclonal gammopathies

Anna Caldini, Maria Stella Graziani, Umberto Basile, Ivana Cataldo, Giovanni Cigliana, Maria Teresa Muratore, Michele Mussap, Alessandro Terreni, Arialdo Vernocchi, Giampaolo Merlini

Research output: Contribution to journalArticlepeer-review


This document examines laboratory tests to be used for the management of monoclonal gammopathies in different clinical scenarios, from screening to monitoring and assessment of the response to therapy. The content is based on international recommendations and guidelines currently available. It includes sections on the analytical aspects of different tests (serum protein electrophoresis, typing and quantification of monoclonal components, Bence Jones protein determination and free light chain measurement) and on their clinical significance as well. Different clinical settings are examined: screening, diagnosis, risk stratification, monitoring and response assessment. For each of those, laboratory tests to be used are indicated. Aim of the document is to help clinical laboratories avoiding unnecessary tests, ensuring in the meantime that all the investigations required for a optimal patient management are carried out.

Translated title of the contributionProtein diagnostics in the management of monoclonal gammopathies
Original languageItalian
Pages (from-to)47-53
Number of pages7
JournalBiochimica Clinica
Issue number1
Publication statusPublished - Feb 2014

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Medical Laboratory Technology


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