This document examines laboratory tests to be used for the management of monoclonal gammopathies in different clinical scenarios, from screening to monitoring and assessment of the response to therapy. The content is based on international recommendations and guidelines currently available. It includes sections on the analytical aspects of different tests (serum protein electrophoresis, typing and quantification of monoclonal components, Bence Jones protein determination and free light chain measurement) and on their clinical significance as well. Different clinical settings are examined: screening, diagnosis, risk stratification, monitoring and response assessment. For each of those, laboratory tests to be used are indicated. Aim of the document is to help clinical laboratories avoiding unnecessary tests, ensuring in the meantime that all the investigations required for a optimal patient management are carried out.
|Translated title of the contribution||Protein diagnostics in the management of monoclonal gammopathies|
|Number of pages||7|
|Publication status||Published - Feb 2014|
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical
- Medical Laboratory Technology