Protein homeostasis in neurons and its pathological alterations

Research output: Contribution to journalArticlepeer-review

Abstract

In neuronal cells, proteins are synthesized on ribosomes from the genetic information encoded in DNA. In some instances translation takes place at the neuronal cell soma but in other it occurs at distal location, such as in a dendritic spine. Folding is usually initiated before the completion of protein synthesis and its outcome strictly depends on the local environment in which the nascent protein is submerged. Incompletely folded proteins and, more importantly, misfolded proteins are under the surveillance of several quality control systems that re-establish the correct conformation or initiate protein degradation. Regulation and maintenance of these systems is a vital issue for neuronal and glial cells, and impairments at different levels leads to neurodegenerative diseases.

Original languageEnglish
Pages (from-to)270-274
Number of pages5
JournalCurrent Opinion in Neurobiology
Volume16
Issue number3
DOIs
Publication statusPublished - Jun 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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