Protein kinase A activity in platelets from patients with bipolar disorder

Daniela Tardito; Silvia Mori; Giorgio Racagni; Enrico Smeraldi; Raffaella Zanardi; Jorge Perez

doi:10.1016/S0165-0327(02)00065-4

Protein kinase A activity in platelets from patients with bipolar disorder

Daniela Tardito, Silvia Mori, Giorgio Racagni, Enrico Smeraldi, Raffaella Zanardi, Jorge Perez

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Abnormal levels of protein kinase A (PKA) were found in patients with bipolar disorder (BD). Since altered levels are generally accompanied by functional modifications, the purpose of this study was to investigate PKA activity in patients with BD. Methods: PKA activity was assessed in platelets from 20 drug-free bipolar patients and 19 controls. Results: The cAMP-stimulated PKA activity was significantly increased in bipolar patients compared with controls. Limitations: This study made use of platelets, which may not fully represent changes occurring in specific brain regions. Conclusion: This study adds to the growing evidence suggesting that abnormalities of PKA are associated with BD.

Original language	English
Pages (from-to)	249-253
Number of pages	5
Journal	Journal of Affective Disorders
Volume	76
Issue number	1-3
DOIs	https://doi.org/10.1016/S0165-0327(02)00065-4
Publication status	Published - Sep 2003

Keywords

Bipolar disorder
cAMP signaling
PKA activity
Platelets

ASJC Scopus subject areas

Psychiatry and Mental health
Behavioral Neuroscience
Biological Psychiatry
Neurology
Psychology(all)

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title = "Protein kinase A activity in platelets from patients with bipolar disorder",

abstract = "Background: Abnormal levels of protein kinase A (PKA) were found in patients with bipolar disorder (BD). Since altered levels are generally accompanied by functional modifications, the purpose of this study was to investigate PKA activity in patients with BD. Methods: PKA activity was assessed in platelets from 20 drug-free bipolar patients and 19 controls. Results: The cAMP-stimulated PKA activity was significantly increased in bipolar patients compared with controls. Limitations: This study made use of platelets, which may not fully represent changes occurring in specific brain regions. Conclusion: This study adds to the growing evidence suggesting that abnormalities of PKA are associated with BD.",

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T1 - Protein kinase A activity in platelets from patients with bipolar disorder

AU - Tardito, Daniela

AU - Mori, Silvia

AU - Racagni, Giorgio

AU - Smeraldi, Enrico

AU - Zanardi, Raffaella

AU - Perez, Jorge

PY - 2003/9

Y1 - 2003/9

N2 - Background: Abnormal levels of protein kinase A (PKA) were found in patients with bipolar disorder (BD). Since altered levels are generally accompanied by functional modifications, the purpose of this study was to investigate PKA activity in patients with BD. Methods: PKA activity was assessed in platelets from 20 drug-free bipolar patients and 19 controls. Results: The cAMP-stimulated PKA activity was significantly increased in bipolar patients compared with controls. Limitations: This study made use of platelets, which may not fully represent changes occurring in specific brain regions. Conclusion: This study adds to the growing evidence suggesting that abnormalities of PKA are associated with BD.

AB - Background: Abnormal levels of protein kinase A (PKA) were found in patients with bipolar disorder (BD). Since altered levels are generally accompanied by functional modifications, the purpose of this study was to investigate PKA activity in patients with BD. Methods: PKA activity was assessed in platelets from 20 drug-free bipolar patients and 19 controls. Results: The cAMP-stimulated PKA activity was significantly increased in bipolar patients compared with controls. Limitations: This study made use of platelets, which may not fully represent changes occurring in specific brain regions. Conclusion: This study adds to the growing evidence suggesting that abnormalities of PKA are associated with BD.

KW - Bipolar disorder

KW - cAMP signaling

KW - PKA activity

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