Protein kinase A activity in platelets from patients with bipolar disorder

Daniela Tardito; Silvia Mori; Giorgio Racagni; Enrico Smeraldi; Raffaella Zanardi; Jorge Perez

doi:10.1016/S0165-0327(02)00065-4

Protein kinase A activity in platelets from patients with bipolar disorder

Daniela Tardito, Silvia Mori, Giorgio Racagni, Enrico Smeraldi, Raffaella Zanardi, Jorge Perez

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article

Abstract

Background: Abnormal levels of protein kinase A (PKA) were found in patients with bipolar disorder (BD). Since altered levels are generally accompanied by functional modifications, the purpose of this study was to investigate PKA activity in patients with BD. Methods: PKA activity was assessed in platelets from 20 drug-free bipolar patients and 19 controls. Results: The cAMP-stimulated PKA activity was significantly increased in bipolar patients compared with controls. Limitations: This study made use of platelets, which may not fully represent changes occurring in specific brain regions. Conclusion: This study adds to the growing evidence suggesting that abnormalities of PKA are associated with BD.

Original language	English
Pages (from-to)	249-253
Number of pages	5
Journal	Journal of Affective Disorders
Volume	76
Issue number	1-3
DOIs	https://doi.org/10.1016/S0165-0327(02)00065-4
Publication status	Published - Sep 2003

Fingerprint

Keywords

Bipolar disorder
cAMP signaling
PKA activity
Platelets

ASJC Scopus subject areas

Psychiatry and Mental health
Behavioral Neuroscience
Biological Psychiatry
Neurology
Psychology(all)

Cite this

Tardito, D., Mori, S., Racagni, G., Smeraldi, E., Zanardi, R., & Perez, J. (2003). Protein kinase A activity in platelets from patients with bipolar disorder. Journal of Affective Disorders, 76(1-3), 249-253. https://doi.org/10.1016/S0165-0327(02)00065-4

@article{35c0879dc4234f3b8c868a7d1164207c,

title = "Protein kinase A activity in platelets from patients with bipolar disorder",

abstract = "Background: Abnormal levels of protein kinase A (PKA) were found in patients with bipolar disorder (BD). Since altered levels are generally accompanied by functional modifications, the purpose of this study was to investigate PKA activity in patients with BD. Methods: PKA activity was assessed in platelets from 20 drug-free bipolar patients and 19 controls. Results: The cAMP-stimulated PKA activity was significantly increased in bipolar patients compared with controls. Limitations: This study made use of platelets, which may not fully represent changes occurring in specific brain regions. Conclusion: This study adds to the growing evidence suggesting that abnormalities of PKA are associated with BD.",

keywords = "Bipolar disorder, cAMP signaling, PKA activity, Platelets",

author = "Daniela Tardito and Silvia Mori and Giorgio Racagni and Enrico Smeraldi and Raffaella Zanardi and Jorge Perez",

year = "2003",

month = sep

doi = "10.1016/S0165-0327(02)00065-4",

language = "English",

volume = "76",

pages = "249--253",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier",

number = "1-3",

}

TY - JOUR

T1 - Protein kinase A activity in platelets from patients with bipolar disorder

AU - Tardito, Daniela

AU - Mori, Silvia

AU - Racagni, Giorgio

AU - Smeraldi, Enrico

AU - Zanardi, Raffaella

AU - Perez, Jorge

PY - 2003/9

Y1 - 2003/9

N2 - Background: Abnormal levels of protein kinase A (PKA) were found in patients with bipolar disorder (BD). Since altered levels are generally accompanied by functional modifications, the purpose of this study was to investigate PKA activity in patients with BD. Methods: PKA activity was assessed in platelets from 20 drug-free bipolar patients and 19 controls. Results: The cAMP-stimulated PKA activity was significantly increased in bipolar patients compared with controls. Limitations: This study made use of platelets, which may not fully represent changes occurring in specific brain regions. Conclusion: This study adds to the growing evidence suggesting that abnormalities of PKA are associated with BD.

AB - Background: Abnormal levels of protein kinase A (PKA) were found in patients with bipolar disorder (BD). Since altered levels are generally accompanied by functional modifications, the purpose of this study was to investigate PKA activity in patients with BD. Methods: PKA activity was assessed in platelets from 20 drug-free bipolar patients and 19 controls. Results: The cAMP-stimulated PKA activity was significantly increased in bipolar patients compared with controls. Limitations: This study made use of platelets, which may not fully represent changes occurring in specific brain regions. Conclusion: This study adds to the growing evidence suggesting that abnormalities of PKA are associated with BD.

KW - Bipolar disorder

KW - cAMP signaling

KW - PKA activity

KW - Platelets

UR - http://www.scopus.com/inward/record.url?scp=0042009837&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042009837&partnerID=8YFLogxK

U2 - 10.1016/S0165-0327(02)00065-4

DO - 10.1016/S0165-0327(02)00065-4

M3 - Article

C2 - 12943955

AN - SCOPUS:0042009837

VL - 76

SP - 249

EP - 253

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 1-3

ER -

Access to Document

10.1016/S0165-0327(02)00065-4