Abstract
Background: Abnormal levels of protein kinase A (PKA) were found in patients with bipolar disorder (BD). Since altered levels are generally accompanied by functional modifications, the purpose of this study was to investigate PKA activity in patients with BD. Methods: PKA activity was assessed in platelets from 20 drug-free bipolar patients and 19 controls. Results: The cAMP-stimulated PKA activity was significantly increased in bipolar patients compared with controls. Limitations: This study made use of platelets, which may not fully represent changes occurring in specific brain regions. Conclusion: This study adds to the growing evidence suggesting that abnormalities of PKA are associated with BD.
| Original language | English |
|---|---|
| Pages (from-to) | 249-253 |
| Number of pages | 5 |
| Journal | Journal of Affective Disorders |
| Volume | 76 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - Sep 2003 |
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Keywords
- Bipolar disorder
- cAMP signaling
- PKA activity
- Platelets
ASJC Scopus subject areas
- Psychiatry and Mental health
- Behavioral Neuroscience
- Biological Psychiatry
- Neurology
- Psychology(all)
Cite this
Protein kinase A activity in platelets from patients with bipolar disorder. / Tardito, Daniela; Mori, Silvia; Racagni, Giorgio; Smeraldi, Enrico; Zanardi, Raffaella; Perez, Jorge.
In: Journal of Affective Disorders, Vol. 76, No. 1-3, 09.2003, p. 249-253.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Protein kinase A activity in platelets from patients with bipolar disorder
AU - Tardito, Daniela
AU - Mori, Silvia
AU - Racagni, Giorgio
AU - Smeraldi, Enrico
AU - Zanardi, Raffaella
AU - Perez, Jorge
PY - 2003/9
Y1 - 2003/9
N2 - Background: Abnormal levels of protein kinase A (PKA) were found in patients with bipolar disorder (BD). Since altered levels are generally accompanied by functional modifications, the purpose of this study was to investigate PKA activity in patients with BD. Methods: PKA activity was assessed in platelets from 20 drug-free bipolar patients and 19 controls. Results: The cAMP-stimulated PKA activity was significantly increased in bipolar patients compared with controls. Limitations: This study made use of platelets, which may not fully represent changes occurring in specific brain regions. Conclusion: This study adds to the growing evidence suggesting that abnormalities of PKA are associated with BD.
AB - Background: Abnormal levels of protein kinase A (PKA) were found in patients with bipolar disorder (BD). Since altered levels are generally accompanied by functional modifications, the purpose of this study was to investigate PKA activity in patients with BD. Methods: PKA activity was assessed in platelets from 20 drug-free bipolar patients and 19 controls. Results: The cAMP-stimulated PKA activity was significantly increased in bipolar patients compared with controls. Limitations: This study made use of platelets, which may not fully represent changes occurring in specific brain regions. Conclusion: This study adds to the growing evidence suggesting that abnormalities of PKA are associated with BD.
KW - Bipolar disorder
KW - cAMP signaling
KW - PKA activity
KW - Platelets
UR - http://www.scopus.com/inward/record.url?scp=0042009837&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042009837&partnerID=8YFLogxK
U2 - 10.1016/S0165-0327(02)00065-4
DO - 10.1016/S0165-0327(02)00065-4
M3 - Article
C2 - 12943955
AN - SCOPUS:0042009837
VL - 76
SP - 249
EP - 253
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 1-3
ER -