Protein kinase A activity in platelets from patients with bipolar disorder

Daniela Tardito, Silvia Mori, Giorgio Racagni, Enrico Smeraldi, Raffaella Zanardi, Jorge Perez

Research output: Contribution to journalArticle

Abstract

Background: Abnormal levels of protein kinase A (PKA) were found in patients with bipolar disorder (BD). Since altered levels are generally accompanied by functional modifications, the purpose of this study was to investigate PKA activity in patients with BD. Methods: PKA activity was assessed in platelets from 20 drug-free bipolar patients and 19 controls. Results: The cAMP-stimulated PKA activity was significantly increased in bipolar patients compared with controls. Limitations: This study made use of platelets, which may not fully represent changes occurring in specific brain regions. Conclusion: This study adds to the growing evidence suggesting that abnormalities of PKA are associated with BD.

Original languageEnglish
Pages (from-to)249-253
Number of pages5
JournalJournal of Affective Disorders
Volume76
Issue number1-3
DOIs
Publication statusPublished - Sep 2003

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Keywords

  • Bipolar disorder
  • cAMP signaling
  • PKA activity
  • Platelets

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Tardito, D., Mori, S., Racagni, G., Smeraldi, E., Zanardi, R., & Perez, J. (2003). Protein kinase A activity in platelets from patients with bipolar disorder. Journal of Affective Disorders, 76(1-3), 249-253. https://doi.org/10.1016/S0165-0327(02)00065-4