Protein profiles in sera of patients with malignant cutaneous melanoma

Lorenza Ferrari, Roberta Seraglia, Carlo Riccardo Rossi, Antonella Bertazzo, Mario Lise, Graziella Allegri, Pietro Traldi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Seventeen samples of sera from patients with malignant cutaneous melanoma at various stages and 14 samples from healthy subjects were analysed by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. Results highlighted the presence of several protein species at molecular weights lower than 30000 Da, presumably originating from proteolysis, in the sera of the patients with melanoma. These species were completely absent in healthy subjects. In particular, the presence and abundance of species with molecular weights in the range 2500-3500 Da exhibit significant variations related to the different clinical stages of the disease. Copyright (C) 2000 John Wiley and Sons, Ltd.

Original languageEnglish
Pages (from-to)1149-1154
Number of pages6
JournalRapid Communications in Mass Spectrometry
Volume14
Issue number13
DOIs
Publication statusPublished - 2000

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Molecular weight
Proteolysis
Ionization
Mass spectrometry
Desorption
Proteins
Lasers

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

Cite this

Protein profiles in sera of patients with malignant cutaneous melanoma. / Ferrari, Lorenza; Seraglia, Roberta; Rossi, Carlo Riccardo; Bertazzo, Antonella; Lise, Mario; Allegri, Graziella; Traldi, Pietro.

In: Rapid Communications in Mass Spectrometry, Vol. 14, No. 13, 2000, p. 1149-1154.

Research output: Contribution to journalArticle

Ferrari, Lorenza ; Seraglia, Roberta ; Rossi, Carlo Riccardo ; Bertazzo, Antonella ; Lise, Mario ; Allegri, Graziella ; Traldi, Pietro. / Protein profiles in sera of patients with malignant cutaneous melanoma. In: Rapid Communications in Mass Spectrometry. 2000 ; Vol. 14, No. 13. pp. 1149-1154.
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