Protein S and protein C anticoagulant activity in acute and chronic cardiac ischemic syndromes. Relationship to inflammation, complement activation and in vivo thrombin activity

Armando D'Angelo; Stefano Gerosa; Silvana Vigano' D'Angelo; Alessandra Mailhac; Alessandro Colombo; Alberto Agazzi; Giuseppina Mazzola; Sergio Chierchia

doi:10.1016/0049-3848(94)90062-0

Protein S and protein C anticoagulant activity in acute and chronic cardiac ischemic syndromes. Relationship to inflammation, complement activation and in vivo thrombin activity

Armando D'Angelo, Stefano Gerosa, Silvana Vigano' D'Angelo, Alessandra Mailhac, Alessandro Colombo, Alberto Agazzi, Giuseppina Mazzola, Sergio Chierchia

Research output: Contribution to journal › Article › peer-review

Abstract

Protein S (PS) and protein C (PC) anticoagulant activities and thrombin-antithrombin complex (TAT) were measured in 20 patients with AIS, 25 patients with chronic stable angina (CSA) and a control group (C). Although plasma levels of TAT were significantly elevated in patients with CSA (p p>0.005 vs C). In addition, the ratios of anticoagulant PC and PS to factor IX were lower in patients with AIS than in those with CSA (p

Original language	English
Pages (from-to)	133-142
Number of pages	10
Journal	Thrombosis Research
Volume	75
Issue number	2
DOIs	https://doi.org/10.1016/0049-3848(94)90062-0
Publication status	Published - Jul 15 1994

Keywords

complement
hypercoagulability
ischemic heart disease
protein S
thrombin-antithrombin complex
vitamin K-dependent factors
von Willebrand factor

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Hematology

Access to Document

10.1016/0049-3848(94)90062-0

Cite this

D'Angelo, A., Gerosa, S., Vigano' D'Angelo, S., Mailhac, A., Colombo, A., Agazzi, A., Mazzola, G., & Chierchia, S. (1994). Protein S and protein C anticoagulant activity in acute and chronic cardiac ischemic syndromes. Relationship to inflammation, complement activation and in vivo thrombin activity. Thrombosis Research, 75(2), 133-142. https://doi.org/10.1016/0049-3848(94)90062-0

Protein S and protein C anticoagulant activity in acute and chronic cardiac ischemic syndromes. Relationship to inflammation, complement activation and in vivo thrombin activity. / D'Angelo, Armando; Gerosa, Stefano; Vigano' D'Angelo, Silvana et al.

In: Thrombosis Research, Vol. 75, No. 2, 15.07.1994, p. 133-142.

Research output: Contribution to journal › Article › peer-review

D'Angelo, A, Gerosa, S, Vigano' D'Angelo, S, Mailhac, A, Colombo, A, Agazzi, A, Mazzola, G & Chierchia, S 1994, 'Protein S and protein C anticoagulant activity in acute and chronic cardiac ischemic syndromes. Relationship to inflammation, complement activation and in vivo thrombin activity', Thrombosis Research, vol. 75, no. 2, pp. 133-142. https://doi.org/10.1016/0049-3848(94)90062-0

@article{6cd150b900bf475497a1e5be32aaf293,

title = "Protein S and protein C anticoagulant activity in acute and chronic cardiac ischemic syndromes. Relationship to inflammation, complement activation and in vivo thrombin activity",

abstract = "Protein S (PS) and protein C (PC) anticoagulant activities and thrombin-antithrombin complex (TAT) were measured in 20 patients with AIS, 25 patients with chronic stable angina (CSA) and a control group (C). Although plasma levels of TAT were significantly elevated in patients with CSA (p p>0.005 vs C). In addition, the ratios of anticoagulant PC and PS to factor IX were lower in patients with AIS than in those with CSA (p",

keywords = "complement, hypercoagulability, ischemic heart disease, protein S, thrombin-antithrombin complex, vitamin K-dependent factors, von Willebrand factor",

author = "Armando D'Angelo and Stefano Gerosa and {Vigano' D'Angelo}, Silvana and Alessandra Mailhac and Alessandro Colombo and Alberto Agazzi and Giuseppina Mazzola and Sergio Chierchia",

year = "1994",

month = jul,

day = "15",

doi = "10.1016/0049-3848(94)90062-0",

language = "English",

volume = "75",

pages = "133--142",

journal = "Thrombosis Research",

issn = "0049-3848",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Protein S and protein C anticoagulant activity in acute and chronic cardiac ischemic syndromes. Relationship to inflammation, complement activation and in vivo thrombin activity

AU - D'Angelo, Armando

AU - Gerosa, Stefano

AU - Vigano' D'Angelo, Silvana

AU - Mailhac, Alessandra

AU - Colombo, Alessandro

AU - Agazzi, Alberto

AU - Mazzola, Giuseppina

AU - Chierchia, Sergio

PY - 1994/7/15

Y1 - 1994/7/15

N2 - Protein S (PS) and protein C (PC) anticoagulant activities and thrombin-antithrombin complex (TAT) were measured in 20 patients with AIS, 25 patients with chronic stable angina (CSA) and a control group (C). Although plasma levels of TAT were significantly elevated in patients with CSA (p p>0.005 vs C). In addition, the ratios of anticoagulant PC and PS to factor IX were lower in patients with AIS than in those with CSA (p

AB - Protein S (PS) and protein C (PC) anticoagulant activities and thrombin-antithrombin complex (TAT) were measured in 20 patients with AIS, 25 patients with chronic stable angina (CSA) and a control group (C). Although plasma levels of TAT were significantly elevated in patients with CSA (p p>0.005 vs C). In addition, the ratios of anticoagulant PC and PS to factor IX were lower in patients with AIS than in those with CSA (p

KW - complement

KW - hypercoagulability

KW - ischemic heart disease

KW - protein S

KW - thrombin-antithrombin complex

KW - vitamin K-dependent factors

KW - von Willebrand factor

UR - http://www.scopus.com/inward/record.url?scp=0027937583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027937583&partnerID=8YFLogxK

U2 - 10.1016/0049-3848(94)90062-0

DO - 10.1016/0049-3848(94)90062-0

M3 - Article

C2 - 7974387

AN - SCOPUS:0027937583

VL - 75

SP - 133

EP - 142

JO - Thrombosis Research

JF - Thrombosis Research

SN - 0049-3848

IS - 2

ER -

Protein S and protein C anticoagulant activity in acute and chronic cardiac ischemic syndromes. Relationship to inflammation, complement activation and in vivo thrombin activity

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this