Protein S and protein C anticoagulant activity in acute and chronic cardiac ischemic syndromes. Relationship to inflammation, complement activation and in vivo thrombin activity

Armando D'Angelo, Stefano Gerosa, Silvana Vigano' D'Angelo, Alessandra Mailhac, Alessandro Colombo, Alberto Agazzi, Giuseppina Mazzola, Sergio Chierchia

Research output: Contribution to journalArticle

Abstract

Protein S (PS) and protein C (PC) anticoagulant activities and thrombin-antithrombin complex (TAT) were measured in 20 patients with AIS, 25 patients with chronic stable angina (CSA) and a control group (C). Although plasma levels of TAT were significantly elevated in patients with CSA (p p>0.005 vs C). In addition, the ratios of anticoagulant PC and PS to factor IX were lower in patients with AIS than in those with CSA (p

Original languageEnglish
Pages (from-to)133-142
Number of pages10
JournalThrombosis Research
Volume75
Issue number2
DOIs
Publication statusPublished - Jul 15 1994

Keywords

  • complement
  • hypercoagulability
  • ischemic heart disease
  • protein S
  • thrombin-antithrombin complex
  • vitamin K-dependent factors
  • von Willebrand factor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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