Protein synthesis inhibition induced by dimethylnitrosamine and diethylnitrosamine on isolated rat hepatocytes

Elisabetta Mattei, Andrea Delpino, U. Ferrini

Research output: Contribution to journalArticle

Abstract

Time- and dose-dependent protein synthesis inhibition takes place following exposure to high doses of dimethylnitrosamine (DMN) or diethylnitrosamine (DENA) in isolated rat hepatocytes. The ability of DENA to depress protein synthesis is 5-fold higher than that of DMN. Cells inhibited by 60 min exposure to DMN or DENA, and then incubated in a nitrosamine-free medium, regain their initial rate of protein synthesis. This recovery is faster and more complete for DENA-treated cells.

Original languageEnglish
Pages (from-to)1213-1215
Number of pages3
JournalExperientia
Volume35
Issue number9
DOIs
Publication statusPublished - Sep 1979

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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