Proteomic analysis of mitochondrial dysfunction in neurodegenerative diseases

Carlo Rodolfo, Fabiola Ciccosanti, Giuseppina Di Giacomo, Mauro Piacentini, Gian Maria Fimia

Research output: Contribution to journalArticle

Abstract

Alzheimers, Parkinsons and Huntingtons disease, and amyotrophic lateral sclerosis are the most relevant neurodegenerative syndromes worldwide. The identification of the etiology and additional factors contributing to the onset and progression of these diseases is of great importance in order to develop both preventive and therapeutic intervention. A common feature of these pathologies is the formation of aggregates, containing mutated and/or misfolded proteins, in specific subsets of neurons, which progressively undergo functional impairment and die. The relationship between protein aggregation and the molecular events leading to neurodegeneration has not yet been clarified. In the last decade, several lines of evidence pointed to a major role for mitochondrial dysfunction in the onset of these pathologies. Here, we review how proteomics has been applied to neurodegenerative diseases in order to characterize the relationship existing between protein aggregation and mitochondrial alterations. Moreover, we highlight recent advances in the use of proteomics to identify protein modifications caused by oxidative stress. Future developments in this field are expected to significantly contribute to the full comprehension of the molecular mechanisms at the heart of neurodegeneration.

Original languageEnglish
Pages (from-to)519-542
Number of pages24
JournalExpert Review of Proteomics
Volume7
Issue number4
DOIs
Publication statusPublished - Aug 2010

Keywords

  • Alzheimer
  • amyotrophic lateral sclerosis
  • Huntington
  • mitochondria
  • oxidative stress
  • Parkinson

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry

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