Proteomic analysis of peritoneal fluid in women with endometriosis

Simone Ferrero; David J. Gillott; Valentino Remorgida; Paola Anserini; Kit Yi Leung; Nicola Ragni; Jurgis G. Grudzinskas

doi:10.1021/pr060680q

Proteomic analysis of peritoneal fluid in women with endometriosis

Simone Ferrero, David J. Gillott, Valentino Remorgida, Paola Anserini, Kit Yi Leung, Nicola Ragni, Jurgis G. Grudzinskas

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

This study aims to evaluate differences in the expression of proteins present in the peritoneal fluid (PF) of women with and without endometriosis. PF samples were subjected to two-dimensional gel electrophoresis; protein spots of interest were identified by liquid chromatography tandem mass spectrometry. Several molecules had aberrant expression in PF of women with endometriosis; they may be useful for a better understanding of the pathogenesis of this disease.

Original language	English
Pages (from-to)	3402-3411
Number of pages	10
Journal	Journal of Proteome Research
Volume	6
Issue number	9
DOIs	https://doi.org/10.1021/pr060680q
Publication status	Published - Sep 2007

Keywords

Endometriosis
Peritoneal fluid
Proteomics
Tandem mass spectrometry
Two-dimensional gel electrophoresis

ASJC Scopus subject areas

Genetics
Biotechnology
Biochemistry

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10.1021/pr060680q

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keywords = "Endometriosis, Peritoneal fluid, Proteomics, Tandem mass spectrometry, Two-dimensional gel electrophoresis",

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AU - Gillott, David J.

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AU - Anserini, Paola

AU - Leung, Kit Yi

AU - Ragni, Nicola

AU - Grudzinskas, Jurgis G.

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AB - This study aims to evaluate differences in the expression of proteins present in the peritoneal fluid (PF) of women with and without endometriosis. PF samples were subjected to two-dimensional gel electrophoresis; protein spots of interest were identified by liquid chromatography tandem mass spectrometry. Several molecules had aberrant expression in PF of women with endometriosis; they may be useful for a better understanding of the pathogenesis of this disease.

KW - Endometriosis

KW - Peritoneal fluid

KW - Proteomics

KW - Tandem mass spectrometry

KW - Two-dimensional gel electrophoresis

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Proteomic analysis of peritoneal fluid in women with endometriosis

Abstract

Keywords

ASJC Scopus subject areas

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