Proteomic knowledge of human aquaporins

Fulvio Magni, Cecilia Sarto, Davide Ticozzi, Monica Soldi, Niccolò Bosso, Paolo Mocarelli, Marzia Galli Kienle

Research output: Contribution to journalArticlepeer-review

Abstract

Aquaporins (AQPs) are an ubiquitous family of proteins characterized by sequence similarity and the presence of two NPA (Asp-Pro-Ala) motifs. At present, 13 human AQPs are known and they are divided into two subgroups according to their ability to transport only water molecules (AQPO, AQP1, AQP2, AQP4, AQP5, AQP6, and AQP8), or also glycerol and other small solutes (AQP3, AQP7, AQP9, AQP10, AQP12). The genomic, structural, and functional aspects of this family are briefly described. In particular, proteomic approaches to identify and characterize the most studied AQPs, mainly through SDS-PAGE followed by MS analysis, are discussed. Moreover, the clinical importance of the best studied aquaporin (AQP1) in human diseases is also provided.

Original languageEnglish
Pages (from-to)5637-5649
Number of pages13
JournalProteomics
Volume6
Issue number20
DOIs
Publication statusPublished - Oct 2006

Keywords

  • Aquaporin
  • Post-translational modifications

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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