Proteomics and cardiovascular disease

An update

Maria Luisa Balestrieri, Alfonso Giovane, Francesco Paolo Mancini, Claudio Napoli

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Proteomics has unraveled important questions in the biology of cardiovascular disease and holds even greater promise for the development of novel diagnostic and prognostic biomarkers. This approach may establish early detection strategies, and monitor responses to therapies. Technological advances (most notably blue native polyacrylamide gel electrophoresis, electrospray ionization, matrix-assisted laser desorption/ionization (MALDI), analysis of MALDI-derived peptides in Time-of-Flight (TOF) analyzers, and multidimensional protein identification technology (MudPIT) and bioinformatics for data handling and interpretation allow a large-scale identification of peptide sequence and post-translational modifications. Moreover, combination of proteomic biomarkers with clinical phenotype, metabolite changes, and genetic haplotype information is promising for the physician assessment of individual cardiovascular risk profile.

Original languageEnglish
Pages (from-to)555-572
Number of pages18
JournalCurrent Medicinal Chemistry
Volume15
Issue number6
DOIs
Publication statusPublished - Mar 2008

Fingerprint

Biomarkers
Proteomics
Ionization
Desorption
Lasers
Cardiovascular Diseases
Native Polyacrylamide Gel Electrophoresis
Electrospray ionization
Peptides
Data handling
Post Translational Protein Processing
Bioinformatics
Metabolites
Computational Biology
Electrophoresis
Haplotypes
Technology
Physicians
Phenotype
Proteins

Keywords

  • Cardiovascular disease
  • Mass spectrometry
  • Proteomics
  • Two-dimensional gel electrophoresis

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Pharmacology

Cite this

Proteomics and cardiovascular disease : An update. / Balestrieri, Maria Luisa; Giovane, Alfonso; Mancini, Francesco Paolo; Napoli, Claudio.

In: Current Medicinal Chemistry, Vol. 15, No. 6, 03.2008, p. 555-572.

Research output: Contribution to journalArticle

Balestrieri, Maria Luisa ; Giovane, Alfonso ; Mancini, Francesco Paolo ; Napoli, Claudio. / Proteomics and cardiovascular disease : An update. In: Current Medicinal Chemistry. 2008 ; Vol. 15, No. 6. pp. 555-572.
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