Proteomics and Metabolomics for Cystic Fibrosis Research

Nara Liessi, Nicoletta Pedemonte, Andrea Armirotti, Clarissa Braccia

Research output: Contribution to journalReview articlepeer-review


The aim of this review article is to introduce the reader to the state-of-the-art of the contribution that proteomics and metabolomics sciences are currently providing for cystic fibrosis (CF) research: from the understanding of cystic fibrosis transmembrane conductance regulator (CFTR) biology to biomarker discovery for CF diagnosis. Our work particularly focuses on CFTR post-translational modifications and their role in cellular trafficking as well as on studies that allowed the identification of CFTR molecular interactors. We also show how metabolomics is currently helping biomarker discovery in CF. The most recent advances in these fields are covered by this review, as well as some considerations on possible future scenarios for new applications.

Original languageEnglish
JournalInt J Mol Sci
Issue number15
Publication statusPublished - Jul 30 2020


  • Biomarkers/metabolism
  • Cystic Fibrosis/diagnosis
  • Cystic Fibrosis Transmembrane Conductance Regulator/genetics
  • Humans
  • Metabolomics
  • Mutation/genetics
  • Protein Interaction Maps/genetics
  • Protein Processing, Post-Translational/genetics
  • Protein Transport/genetics
  • Proteomics


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